Details of the Target

General Information of Target

Target ID LDTP14783
Target Name Metallothionein-1H (MT1H)
Gene Name MT1H
Gene ID 4496
Synonyms
Metallothionein-1H; MT-1H; Metallothionein-0; MT-0; Metallothionein-IH; MT-IH
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSV
LGMYAAAGPYAGAPNYSAFLPYAADLSLFSQMGSQYELKDNPGVHPATFAAHTAPAYYPY
GQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFAN
ARRRLKKENKVTWGARSKDQEDGALFGSDTEGDPEKAEDDEEIDLESIDIDKIDEHDGDQ
SNEDDEDKAEAPHAPAAPSALARDQGSPLAAADVLKPQDSPLGLAKEAPEPGSTRLLSPG
AAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPPPAGHPGAHGPSAGAPLQHPAFLPS
HGLYTCHIGKFSNWTNSAFLAQGSLLNMRSFLGVGAPHAAPHGPHLPAPPPPQPPVAIAP
GALNGDKASVRSSPTLPERDLVPRPDSPAQQLKSPFQPVRDNSLAPQEGTPRILAALPSA
Target Bioclass
Other
Family
Metallothionein superfamily, Type 1 family
Function Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
Uniprot ID
P80294
Ensemble ID
ENST00000332374.5
HGNC ID
HGNC:7400

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C50(2.85)  LDD2229  [1]
BTD
 Probe Info  		C48(1.34)  LDD2089  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C50(1.49); C48(1.08); C26(0.79)  LDD2095  [2]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C48(1.60)  LDD2130  [2]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C50(1.41)  LDD2131  [2]
 LDCM0498  BS-3668 MDA-MB-231 C50(0.85); C48(1.00)  LDD2091  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C48(0.99)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C48(1.34)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C50(1.39)  LDD2093  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C50(0.21)  LDD2096  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C50(0.66); C48(0.42); C44(0.28)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C50(0.27)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C50(0.15)  LDD2124  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C50(0.70); C48(0.40)  LDD2128  [2]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C50(1.67); C48(0.52)  LDD2147  [2]

References

1 A quantitative thiol reactivity profiling platform to analyze redox and electrophile reactive cysteine proteomes. Nat Protoc. 2020 Sep;15(9):2891-2919. doi: 10.1038/s41596-020-0352-2. Epub 2020 Jul 20.
Mass spectrometry data entry: PXD016048
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761