Details of the Target

General Information of Target

Target ID LDTP14744
Target Name Taste receptor type 2 member 30 (TAS2R30)
Gene Name TAS2R30
Gene ID 259293
Synonyms
TAS2R47; Taste receptor type 2 member 30; T2R30; Taste receptor type 2 member 47; T2R47
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLW
VLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLH
LKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVT
ILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAI
YFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYW
VKGEKPSSS
Target Bioclass
GPCR
Family
G-protein coupled receptor T2R family
Subcellular location
Membrane
Function
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5.
Uniprot ID
P59541
Ensemble ID
ENST00000539585.1
HGNC ID
HGNC:19112
ChEMBL ID
CHEMBL4523254

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PF-06672131
 Probe Info  		N.A.  LDD0017  [1]

References

1 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569