Details of the Target
General Information of Target
| Target ID | LDTP14734 | |||||
|---|---|---|---|---|---|---|
| Target Name | Rhomboid-related protein 3 (RHBDL3) | |||||
| Gene Name | RHBDL3 | |||||
| Gene ID | 162494 | |||||
| Synonyms |
RHBDL4; VRHO; Rhomboid-related protein 3; EC 3.4.21.105; Ventrhoid transmembrane protein |
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| 3D Structure | ||||||
| Sequence |
MLLPGRARQPPTPQPVQHPGLRRQVEPPGQLLRLFYCTVLVCSKEISALTDFSGYLTKLL
QNHTTYACDGDYLNLQCPRHSTISVQSAFYGQDYQMCSSQKPASQREDSLTCVAATTFQK VLDECQNQRACHLLVNSRVFGPDLCPGSSKYLLVSFKCQPNELKNKTVCEDQELKLHCHE SKFLNIYSATYGRRTQERDICSSKAERLPPFDCLSYSALQVLSRRCYGKQRCKIIVNNHH FGSPCLPGVKKYLTVTYACVPKNILTAIDPAIANLKPSLKQKDGEYGINFDPSGSKVLRK DGILVSNSLAAFAYIRAHPERAALLFVSSVCIGLALTLCALVIRESCAKDFRDLQLGREQ LVPGSDKVEEDSEDEEEEEDPSESDFPGELSGFCRTSYPIYSSIEAAELAERIERREQII QEIWMNSGLDTSLPRNMGQFY |
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| Target Bioclass |
Enzyme
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| Family |
Peptidase S54 family
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| Subcellular location |
Membrane
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| Function | May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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CY4 Probe Info |
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N.A. | LDD0247 | [1] | |