Details of the Target

General Information of Target

Target ID LDTP14694
Target Name Glioma pathogenesis-related protein 1 (GLIPR1)
Gene Name GLIPR1
Gene ID 11010
Synonyms
GLIPR; RTVP1; Glioma pathogenesis-related protein 1; GliPR 1; Protein RTVP-1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLALLAASVALAVAAGAQDSPAPGSRFVCTALPPEAVHAGCPLPAMPMQGGAQSPEEELR
AAVLQLRETVVQQKETLGAQREAIRELTGKLARCEGLAGGKARGAGATGKDTMGDLPRDP
GHVVEQLSRSLQTLKDRLESLEHQLRANVSNAGLPGDFREVLQQRLGELERQLLRKVAEL
EDEKSLLHNETSAHRQKTESTLNALLQRVTELERGNSAFKSPDAFKVSLPLRTNYLYGKI
KKTLPELYAFTICLWLRSSASPGIGTPFSYAVPGQANEIVLIEWGNNPIELLINDKVAQL
PLFVSDGKWHHICVTWTTRDGMWEAFQDGEKLGTGENLAPWHPIKPGGVLILGQEQDTVG
GRFDATQAFVGELSQFNIWDRVLRAQEIVNIANCSTNMPGNIIPWVDNNVDVFGGASKWP
VETCEERLLDL
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
CRISP family
Subcellular location
Membrane
TTD ID
T70201
Uniprot ID
P48060
DrugMap ID
TTEQF1O
Ensemble ID
ENST00000266659.8
HGNC ID
HGNC:17001

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1B Insertion: p.V134SfsTer13 .
HSC4 SNV: p.E47Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K200(3.31)  LDD3494  [1]
BTD
 Probe Info  		C151(1.11)  LDD2127  [2]
IPM
 Probe Info  		C192(2.24)  LDD1702  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
DBIA
 Probe Info  		C195(1.28); C192(1.09)  LDD0078  [4]
IA-alkyne
 Probe Info  		C75(0.00); C173(0.00)  LDD0162  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [3]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0020  ARS-1620 HCC44 C195(1.28); C192(1.09)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C192(2.24)  LDD1702  [2]
 LDCM0109  NEM HeLa N.A.  LDD0230  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C151(1.11)  LDD2127  [2]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C37(0.14)  LDD2145  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adrtvp-1 . D09RZH
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sot-107 . DB05337

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060