Details of the Target

General Information of Target

Target ID LDTP14666
Target Name Forkhead box protein N2 (FOXN2)
Gene Name FOXN2
Gene ID 3344
Synonyms
HTLF; Forkhead box protein N2; Human T-cell leukemia virus enhancer factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNDFDECGQSAASMYLPGCAYYVAPSDFASKPSFLSQPSSCQMTFPYSSNLAPHVQPVRE
VAFRDYGLERAKWPYRGGGGGGSAGGGSSGGGPGGGGGGAGGYAPYYAAAAAAAAAAAAA
EEAAMQRELLPPAGRRPDVLFKAPEPVCAAPGPPHGPAGAASNFYSAVGRNGILPQGFDQ
FYEAAPGPPFAGPQPPPPPAPPQPEGAADKGDPRTGAGGGGGSPCTKATPGSEPKGAAEG
SGGDGEGPPGEAGAEKSSSAVAPQRSRKKRCPYTKYQIRELEREFFFNVYINKEKRLQLS
RMLNLTDRQVKIWFQNRRMKEKKLNRDRLQYFTGNPLF
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function Binds to the purine-rich region in HTLV-I LTR.
Uniprot ID
P32314
Ensemble ID
ENST00000340553.8
HGNC ID
HGNC:5281

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 Deletion: p.K271RfsTer22 .
HT115 SNV: p.K20N; p.S416A .
HUCCT1 SNV: p.K398E .
IGROV1 Deletion: p.K271RfsTer22 .
LNCaP clone FGC SNV: p.S419N .
TGBC52TKB SNV: p.E252D .
TOV21G Deletion: p.K431NfsTer5 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C390(7.74)  LDD0170  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C390(7.74)  LDD0170  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MHC class II regulatory factor RFX1 (RFX1) RFX family P22670
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
F-box/WD repeat-containing protein 11 (FBXW11) . Q9UKB1

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264