Details of the Target
General Information of Target
| Target ID | LDTP14501 | |||||
|---|---|---|---|---|---|---|
| Target Name | Serpin B7 (SERPINB7) | |||||
| Gene Name | SERPINB7 | |||||
| Gene ID | 8710 | |||||
| Synonyms |
Serpin B7; Megsin; TP55 |
|||||
| 3D Structure | ||||||
| Sequence |
MAKNGLVICILVITLLLDQTTSHTSRLKARKHSKRRVRDKDGDLKTQIEKLWTEVNALKE
IQALQTVCLRGTKVHKKCYLASEGLKHFHEANEDCISKGGILVIPRNSDEINALQDYGKR SLPGVNDFWLGINDMVTEGKFVDVNGIAISFLNWDRAQPNGGKRENCVLFSQSAQGKWSD EACRSSKRYICEFTIPQ |
|||||
| Target Bioclass |
Other
|
|||||
| Family |
Serpin family, Ov-serpin subfamily
|
|||||
| Subcellular location |
Cytoplasm
|
|||||
| Function | Might function as an inhibitor of Lys-specific proteases. Might influence the maturation of megakaryocytes via its action as a serpin. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
| Cell line | Mutation details | Probe for labeling this protein in this cell | |||
|---|---|---|---|---|---|
| DU145 | SNV: p.G202W | DBIA Probe Info | |||
| LS180 | Deletion: p.S85LfsTer3 SNV: . |
. | |||
| MDST8 | SNV: p.S378F | . | |||
| SKMEL28 | SNV: p.C193Ter | . | |||
| SW1271 | SNV: p.N251K | . | |||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C193(1.26) | LDD3337 | [1] | |
|
MPP-AC Probe Info |
 |
N.A. | LDD0428 | [2] | |
Competitor(s) Related to This Target
References