Details of the Target

General Information of Target

Target ID LDTP14471
Target Name Leucine zipper putative tumor suppressor 3 (LZTS3)
Gene Name LZTS3
Gene ID 9762
Synonyms
KIAA0552; PROSAPIP1; Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTAEGPSPPARWHRRLPGLWAAALLLLGLPRLSVRADGKFFVLESQNGSQGLQLEAARLS
CKSRGAHLASADELRRVVQDCSFAVCTTGWLADGTLGTTVCSKGSGEQQIMRAVDVRIES
NPVPGGTYSALCIKDEEKPCGDPPSFPHTILQGRTGLEMGDELLYVCAPGHIMGHRETAF
TLLCNSCGEWYGLVQACGKDEAEAHIDYEDNFPDDRSVSFRELMEDSRTEADEDRGQGDS
SEEAPKQDRLVSISVGRENIARDKVFVPTTGLPGAGSSVPADSPGSRLLQKHLFWFPAEA
FHKPGLEKEVDDDTKKQFSAGDNHSGVKLVPGEPETKVIYGNTDGPSGPFVGKNDSKAGD
PVVSSSDESWLDGYPVTEGAWRKTEAEEEEDGDRGDGSVGLDENVLVTPDQPILVEVKKP
KSSTLTPSEGMTHSSVLPSQMLDVEALALRPVNASETEGIGDGDLTKYQSTLPWRFITEE
SPMATLSYELTSSTLEILTVNTVKQTPNHIPSTIMATTQPPVETTVPEIQDSFPYLLSED
FFGQEGPGPGASEELHPTLESCVGDGCPGLSRGPVIATIVTVLCLLLLLAGVGMVWGYRK
CQHKSSVYKLNVGQRQARHYHQQIEMEKV
Target Bioclass
Other
Family
LZTS3 family
Subcellular location
Synapse
Function May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses.
Uniprot ID
O60299
Ensemble ID
ENST00000329152.7
HGNC ID
HGNC:30139

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Insertion: p.Q182AfsTer7 .
HCT15 SNV: p.L200P .
HDMYZ SNV: p.T522P .
HEC1 SNV: p.R339Q; p.R485Q .
Ishikawa (Heraklio) 02 ER SNV: p.E323D .
KARPAS299 SNV: p.P314Q .
MEWO Insertion: p.S244delinsCPP .
NCIH1299 SNV: p.G195C .
NCIH23 SNV: p.G92C .
RKO SNV: p.S468N .
SKMEL28 SNV: p.P17L .
SUPT1 SNV: p.P181L .
SW1271 SNV: p.M291I .
TOV21G SNV: p.Q322H; p.E330Ter; p.K400N; p.E405Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C154(1.19)  LDD1507  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0174  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C154(1.19)  LDD1507  [1]
 LDCM0215  AC10 HEK-293T C154(1.22)  LDD1508  [1]
 LDCM0226  AC11 HEK-293T C154(0.98)  LDD1509  [1]
 LDCM0270  AC15 HEK-293T C154(0.95)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C154(1.07)  LDD1515  [1]
 LDCM0277  AC18 HEK-293T C154(1.10)  LDD1516  [1]
 LDCM0278  AC19 HEK-293T C154(1.48)  LDD1517  [1]
 LDCM0279  AC2 HEK-293T C154(1.11)  LDD1518  [1]
 LDCM0281  AC21 HEK-293T C154(1.08)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C154(0.93)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C154(1.00)  LDD1524  [1]
 LDCM0286  AC26 HEK-293T C154(0.92)  LDD1525  [1]
 LDCM0287  AC27 HEK-293T C154(1.04)  LDD1526  [1]
 LDCM0289  AC29 HEK-293T C154(0.97)  LDD1528  [1]
 LDCM0290  AC3 HEK-293T C154(1.12)  LDD1529  [1]
 LDCM0292  AC31 HEK-293T C154(0.94)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C154(1.14)  LDD1533  [1]
 LDCM0295  AC34 HEK-293T C154(1.01)  LDD1534  [1]
 LDCM0296  AC35 HEK-293T C154(0.99)  LDD1535  [1]
 LDCM0298  AC37 HEK-293T C154(1.04)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C154(0.91)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C154(1.04)  LDD1542  [1]
 LDCM0304  AC42 HEK-293T C154(1.16)  LDD1543  [1]
 LDCM0305  AC43 HEK-293T C154(1.06)  LDD1544  [1]
 LDCM0307  AC45 HEK-293T C154(1.03)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C154(1.06)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C154(1.11)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C154(1.07)  LDD1551  [1]
 LDCM0313  AC50 HEK-293T C154(1.18)  LDD1552  [1]
 LDCM0314  AC51 HEK-293T C154(1.05)  LDD1553  [1]
 LDCM0316  AC53 HEK-293T C154(1.03)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C154(1.05)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C154(1.06)  LDD1559  [1]
 LDCM0321  AC58 HEK-293T C154(1.13)  LDD1560  [1]
 LDCM0322  AC59 HEK-293T C154(1.17)  LDD1561  [1]
 LDCM0325  AC61 HEK-293T C154(1.06)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C154(1.03)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C154(1.01)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C154(1.10)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C154(1.03)  LDD1570  [1]
 LDCM0372  CL103 HEK-293T C154(1.10)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C154(0.95)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C154(0.54)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C154(0.93)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C154(1.05)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C154(0.99)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C154(0.98)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C154(1.17)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C154(0.93)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C154(0.93)  LDD1608  [1]
 LDCM0405  CL18 HEK-293T C154(0.84)  LDD1609  [1]
 LDCM0406  CL19 HEK-293T C154(0.69)  LDD1610  [1]
 LDCM0409  CL21 HEK-293T C154(0.62)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C154(0.55)  LDD1615  [1]
 LDCM0415  CL27 HEK-293T C154(1.01)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C154(0.88)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C154(0.86)  LDD1622  [1]
 LDCM0419  CL30 HEK-293T C154(0.73)  LDD1623  [1]
 LDCM0420  CL31 HEK-293T C154(0.70)  LDD1624  [1]
 LDCM0422  CL33 HEK-293T C154(0.61)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C154(0.49)  LDD1628  [1]
 LDCM0428  CL39 HEK-293T C154(0.92)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C154(0.89)  LDD1635  [1]
 LDCM0432  CL42 HEK-293T C154(0.86)  LDD1636  [1]
 LDCM0433  CL43 HEK-293T C154(0.72)  LDD1637  [1]
 LDCM0435  CL45 HEK-293T C154(0.68)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C154(0.54)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C154(0.82)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C154(0.86)  LDD1647  [1]
 LDCM0445  CL54 HEK-293T C154(0.86)  LDD1648  [1]
 LDCM0446  CL55 HEK-293T C154(0.78)  LDD1649  [1]
 LDCM0448  CL57 HEK-293T C154(0.74)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C154(0.58)  LDD1653  [1]
 LDCM0451  CL6 HEK-293T C154(0.78)  LDD1654  [1]
 LDCM0455  CL63 HEK-293T C154(1.06)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C154(0.98)  LDD1660  [1]
 LDCM0458  CL66 HEK-293T C154(0.98)  LDD1661  [1]
 LDCM0459  CL67 HEK-293T C154(0.86)  LDD1662  [1]
 LDCM0461  CL69 HEK-293T C154(0.76)  LDD1664  [1]
 LDCM0462  CL7 HEK-293T C154(0.77)  LDD1665  [1]
 LDCM0464  CL71 HEK-293T C154(0.61)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C154(1.06)  LDD1673  [1]
 LDCM0471  CL78 HEK-293T C154(0.88)  LDD1674  [1]
 LDCM0472  CL79 HEK-293T C154(0.81)  LDD1675  [1]
 LDCM0475  CL81 HEK-293T C154(0.72)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C154(0.65)  LDD1680  [1]
 LDCM0481  CL87 HEK-293T C154(1.22)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C154(1.01)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C154(0.62)  LDD1687  [1]
 LDCM0485  CL90 HEK-293T C154(1.05)  LDD1688  [1]
 LDCM0486  CL91 HEK-293T C154(0.97)  LDD1689  [1]
 LDCM0488  CL93 HEK-293T C154(0.78)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C154(0.82)  LDD1693  [1]
 LDCM0494  CL99 HEK-293T C154(1.13)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C154(1.00)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C154(1.12)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019