Details of the Target

General Information of Target

Target ID LDTP14461
Target Name Integral membrane protein 2A (ITM2A)
Gene Name ITM2A
Gene ID 9452
Synonyms
Integral membrane protein 2A; Protein E25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIAISAVSSALLFSLLCEASTVVLLNSTDSSPPTNNFTDIEAALKAQLDSADIPKARRKR
YISQNDMIAILDYHNQVRGKVFPPAANMEYMVWDENLAKSAEAWAATCIWDHGPSYLLRF
LGQNLSVRTGRYRSILQLVKPWYDEVKDYAFPYPQDCNPRCPMRCFGPMCTHYTQMVWAT
SNRIGCAIHTCQNMNVWGSVWRRAVYLVCNYAPKGNWIGEAPYKVGVPCSSCPPSYGGSC
TDNLCFPGVTSNYLYWFK
Target Bioclass
Transporter and channel
Family
ITM2 family
Subcellular location
Membrane
Uniprot ID
O43736
Ensemble ID
ENST00000373298.7
HGNC ID
HGNC:6173

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1666 SNV: p.A72D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C90(2.36)  LDD3423  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0166  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A673 C90(1.84)  LDD2261  [1]
 LDCM0023  KB03 A673 C90(3.28)  LDD2678  [1]
 LDCM0024  KB05 SK-ES1 C90(2.36)  LDD3423  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-7 (CLDN7) Claudin family O95471
Transmembrane emp24 domain-containing protein 9 (TMED9) EMP24/GP25L family Q9BVK6
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High affinity immunoglobulin gamma Fc receptor I (FCGR1A) Immunoglobulin superfamily P12314
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Signaling threshold-regulating transmembrane adapter 1 (SIT1) . Q9Y3P8

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.