Details of the Target

General Information of Target

Target ID LDTP14408
Target Name Protein shisa-8 (SHISA8)
Gene Name SHISA8
Gene ID 440829
Synonyms
C22orf17; Protein shisa-8; Shisa family member 8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRRVLRLLLGCFLTELCARVCRAQERAGHGQLAQLGGVLLLAGGNRSGAASGEASEGAEA
SDAPPTRAPTPDFCRGYFDVMGQWDPPFNCSSGDFIFCCGTCGFRFCCTFKKRRLNQSTC
TNYDTPLWLNTGKPPARKDDPLHDPTKDKTNLIVYIICGVVAVMVLVGIFTKLGLEKAHR
PQREHMSRALADVMRPQGHCNTDHMERDLNIVVHVQHYENMDTRTPINNLHATQMNNAVP
TSPLLQQMGHPHSYPNLGQISNPYEQQPPGKELNKYASLKAVGSSDGDWAVSTLKSPKAD
KVNDDFYTKRRHLAELAAKGNLPLHPVRVEDEPRAFSPEHGPAKQNGQKSRTNKMPPHPL
AYTSTTNFKGWDPNEQSLRRQAYSNKGKLGTAETGSSDPLGTRPQHYPPPQPYFITNSKT
EVTV
Target Bioclass
Transporter and channel
Family
Shisa family
Subcellular location
Membrane
Function May regulate trafficking and current kinetics of AMPA-type glutamate receptor (AMPAR) at synapses.
Uniprot ID
B8ZZ34
Ensemble ID
ENST00000621082.2
HGNC ID
HGNC:18351

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.R91H .
IGROV1 SNV: p.A321T .
KPNYN SNV: p.R289L .
MFE296 SNV: p.R382H .
MFE319 SNV: p.R231P .
NCIH196 SNV: p.C106S .
SKMEL28 SNV: p.G215V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
MPP-AC
 Probe Info  		N.A.  LDD0428  [1]

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.