Details of the Target

General Information of Target

Target ID LDTP14398
Target Name Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (ELAPOR2)
Gene Name ELAPOR2
Gene ID 222223
Synonyms
EIG121L; KIAA1324L; Endosome/lysosome-associated apoptosis and autophagy regulator family member 2; Estrogen-induced gene 121-like protein; hEIG121L
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGVMCLKASDTWASGIRSQPQGCLGKWRSMRCKHTRMHLAHLGNSRQLISLGPPRTRED
GSRISQQVEQSRSQVQAIGEKVSLAQAKIEKIKGSKKAIKVFSSAKYPAPERLQEYGSIF
TDAQDPGLQRRPRHRIQSKQRPLDERALQEKLKDFPVCVSTKPEPEDDAEEGLGGLPSNI
SSVSSLLLFNTTENLYKKYVFLDPLAGAVTKTHVMLGAETEEKLFDAPLSISKREQLEQQ
VPENYFYVPDLGQVPEIDVPSYLPDLPGIANDLMYIADLGPGIAPSAPGTIPELPTFHTE
VAEPLKVDLQDGVLTPPPPPPPPPPAPEVLASAPPLPPSTAAPVGQGARQDDSSSSASPS
VQGAPREVVDPSGGWATLLESIRQAGGIGKAKLRSMKERKLEKQQQKEQEQVRATSQGGH
LMSDLFNKLVMRRKGISGKGPGAGDGPGGAFARVSDSIPPLPPPQQPQAEDEDDWES
Target Bioclass
Other
Family
ELAPOR family
Subcellular location
Cell membrane
Function Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation.
Uniprot ID
A8MWY0
Ensemble ID
ENST00000416314.5
HGNC ID
HGNC:21945

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.Y258C .
CCK81 SNV: p.C890R .
G415 SNV: p.Q365K .
HCT15 SNV: p.S690N; p.G862V .
HSC3 SNV: p.D420Y .
HT29 SNV: p.A834T .
ICC4 SNV: p.R831L .
IGR1 SNV: p.G1002E .
IGR37 SNV: p.P656S .
IGR39 SNV: p.P656S .
Ishikawa (Heraklio) 02 ER SNV: p.L868P .
JURKAT SNV: p.A47D .
KMS11 SNV: p.C921S .
MCAS SNV: p.L774V .
MDAMB436 SNV: p.L275V .
MEWO SNV: p.M266I; p.E439K; p.D532N; p.G985E .
MOLT4 Deletion: p.E1013KfsTer9
SNV: p.M1?;p.F3L;p.K461N		 .
SKMEL2 SNV: p.A606D .
SW1573 Deletion: p.I763FfsTer24 .
SW948 SNV: p.C618F .
UACC257 SNV: p.N169D .
WM793 SNV: p.A823E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		12.06  LDD0318  [1]
IA-alkyne
 Probe Info  		C637(0.00); C827(0.00)  LDD0165  [2]

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060