Details of the Target
General Information of Target
| Target ID | LDTP14295 | |||||
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| Target Name | Scinderin (SCIN) |
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| Gene Name | SCIN | |||||
| Gene ID | 85477 | |||||
| Synonyms |
KIAA1905; Scinderin; Adseverin |
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| 3D Structure | ||||||
| Sequence |
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDF
EGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPMVKSKPALLSGGLRMNKGAITPPR TTSPANTCSPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIISQ MMHVAEYLEWDVTELNPILHEMMEEIDYDHDGTVSLEEWIQGGMTTIPLLVLLGLENNVK DDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVK SKRNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASHLKPECDC GPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKNKMQRANS VTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGL NFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCLRWGGGYE GENLMKILKDIENSTEIMLDRWKFEVIPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFH IMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLEGIA ILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAKELKFASQDLSDQLLEVVGL EGAMEMGQIYTGLKSAGRRLAQCSCVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPM LMGPPPKTGLFCSLVKRTRNRSKE |
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| Target Bioclass |
Other
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| Family |
Villin/gelsolin family
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| Subcellular location |
Cytoplasm, cytoskeleton
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| Function |
Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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Probe 1 Probe Info |
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Y102(14.48); Y617(17.10) | LDD3495 | [1] | |
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DBIA Probe Info |
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C619(2.23) | LDD3409 | [2] | |
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AHL-Pu-1 Probe Info |
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C178(17.98) | LDD0171 | [3] | |
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5E-2FA Probe Info |
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H128(0.00); H7(0.00); H481(0.00); H37(0.00) | LDD2235 | [4] | |
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m-APA Probe Info |
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H128(0.00); H388(0.00); H379(0.00); H7(0.00) | LDD2231 | [4] | |
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NAIA_5 Probe Info |
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C619(0.00); C282(0.00) | LDD2223 | [5] | |
Competitor(s) Related to This Target
References