Details of the Target

General Information of Target

Target ID LDTP14287
Target Name Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)
Gene Name TNFRSF11A
Gene ID 8792
Synonyms
RANK; Tumor necrosis factor receptor superfamily member 11A; Osteoclast differentiation factor receptor; ODFR; Receptor activator of NF-KB; CD antigen CD265
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSASAVFILDVKGKPLISRNYKGDVAMSKIEHFMPLLVQREEEGALAPLLSHGQVHFLWI
KHSNLYLVATTSKNANASLVYSFLYKTIEVFCEYFKELEEESIRDNFVIVYELLDELMDF
GFPQTTDSKILQEYITQQSNKLETGKSRVPPTVTNAVSWRSEGIKYKKNEVFIDVIESVN
LLVNANGSVLLSEIVGTIKLKVFLSGMPELRLGLNDRVLFELTGRSKNKSVELEDVKFHQ
CVRLSRFDNDRTISFIPPDGDFELMSYRLSTQVKPLIWIESVIEKFSHSRVEIMVKAKGQ
FKKQSVANGVEISVPVPSDADSPRFKTSVGSAKYVPERNVVIWSIKSFPGGKEYLMRAHF
GLPSVEKEEVEGRPPIGVKFEIPYFTVSGIQVRYMKIIEKSGYQALPWVRYITQSGDYQL
RTS
Target Type
Literature-reported
Target Bioclass
Cytokine and receptor
Subcellular location
Cell membrane
Function
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells.
TTD ID
T24800
Uniprot ID
Q9Y6Q6
DrugMap ID
TTK9HGZ
Ensemble ID
ENST00000269485.11
HGNC ID
HGNC:11908

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.A241HfsTer17 .
LNCaP clone FGC SNV: p.G585D .
MOLT4 SNV: p.S375Y .
NALM6 SNV: p.R110W .
NCIH1703 SNV: p.P586S .
PC9 SNV: p.C169R .
SNGM SNV: p.R587C .
WM2664 Insertion: p.A227GfsTer10 .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Isis 109490 Antisense drug D0U7AA
Isis 109491 Antisense drug D02VPR
Isis 109502 Antisense drug D0E8GT
Isis 109524 Antisense drug D07HSU
Isis 109525 Antisense drug D01TAJ
Isis 109526 Antisense drug D02ZTS
Enmd-1198 Small molecular drug DB05959

References

1 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.