Details of the Target

General Information of Target

Target ID LDTP14184
Target Name Sodium channel protein type 10 subunit alpha (SCN10A)
Gene Name SCN10A
Gene ID 6336
Synonyms
Sodium channel protein type 10 subunit alpha; Peripheral nerve sodium channel 3; PN3; hPN3; Sodium channel protein type X subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.8
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARCFSLVLLLTSIWTTRLLVQGSLRAEELSIQVSCRIMGITLVSKKANQQLNFTEAKEA
CRLLGLSLAGKDQVETALKASFETCSYGWVGDGFVVISRISPNPKCGKNGVGVLIWKVPV
SRQFAAYCYNSSDTWTNSCIPEIITTKDPIFNTQTATQTTEFIVSDSTYSVASPYSTIPA
PTTTPPAPASTSIPRRKKLICVTEVFMETSTMSTETEPFVENKAAFKNEAAGFGGVPTAL
LVLALLFFGAAAGLGFCYVKRYVKAFPFTNKNQQKEMIETKVVKEEKANDSNPNEESKKT
DKNPEESKSPSKTTVRCLEAEV
Target Type
Successful
Target Bioclass
Transporter and channel
Family
Sodium channel (TC 1.A.1.10) family, Nav1.8/SCN10A subfamily
Subcellular location
Cell membrane
Function
Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.
TTD ID
T43739
Uniprot ID
Q9Y5Y9
DrugMap ID
TT90XZ8
Ensemble ID
ENST00000449082.3
HGNC ID
HGNC:10582
ChEMBL ID
CHEMBL5451

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 29 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzocaine Small molecular drug DB01086
Brivaracetam Small molecular drug DB05541
Bupivacaine Small molecular drug D0A0FL
Carbamazepine Small molecular drug DB00564
Chloroprocaine Small molecular drug DB01161
Cinchocaine Small molecular drug DB00527
Cocaine Small molecular drug DB00907
Dyclonine Small molecular drug DB00645
Hexylcaine Small molecular drug DB00473
Lacosamide Small molecular drug DB06218
Lamotrigine Small molecular drug DB00555
Levobupivacaine Small molecular drug DB01002
Lidocaine Small molecular drug DB00281
Mepivacaine Small molecular drug DB00961
Orphenadrine Small molecular drug DB01173
Oxybuprocaine Small molecular drug DB00892
Procaine Small molecular drug DB00721
Promethazine Small molecular drug DB01069
Proparacaine Small molecular drug D0Q7ZG
Ranolazine Small molecular drug DB00243
Rilpivirine Small molecular drug D0T6WN
Ropivacaine Small molecular drug D09RHQ
Tetracaine Small molecular drug D08HQK
Tiapride Small molecular drug D02LCR
Topiramate Small molecular drug DB00273
Valproic Acid Small molecular drug DB00313
Bioallethrin . DB13746
Fish Oil . DB13961
Pentoxyverine . DB11186
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Conatumumab Monoclonal antibody D00WME
Vx-150 . D01KWJ
Phase 1
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pf-01247324 Small molecular drug D04JZH
Dsp-2230 . D0VE7B
Vx-128 . D0V5HA
Investigative
Click To Hide/Show 12 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-[5-(4-chlorophenyl)-2-furoyl]Piperazine Small molecular drug D01AGR
5-(4-chlorophenyl)-n-(2-methylbenzyl)Nicotinamide Small molecular drug D02CQN
A-803467 Small molecular drug D0FF6S
Batrachotoxin Small molecular drug D0G9WE
Bw-202w92 Small molecular drug D0B9UU
N-(2-chlorobenzyl)-5-(4-chlorophenyl)Nicotinamide Small molecular drug D0O0JO
N-benzyl-5-(4-chlorophenyl)Nicotinamide Small molecular drug D0W2BP
Pd-32577 Small molecular drug D08RJC
Veratridine Small molecular drug D0S4MN
Cr-4892 . D09ZUM
Sch-725737 . D0F5WY
Sch-725739 . D01EQU
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sipatrigine Small molecular drug D0EC2K
Corus 1030 . D08FZT

References

1 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.