Details of the Target

General Information of Target

Target ID LDTP13948
Target Name Kallikrein-5 (KLK5)
Gene Name KLK5
Gene ID 25818
Synonyms
SCTE; Kallikrein-5; EC 3.4.21.-; Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFSYPSHGWIYPGPVVHGY
WFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNCTLSIRDARRSDAGRYFFR
MEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQNLTCSVPWACEQGTPPMISW
IGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFPGASVTTNKTVHLNVSYPPQNLT
MTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDAVDSNPPARLSLSWRGLTLCPSQPS
NPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLNVSLQSKATSGVTQGVVGGAGATALVF
LSFCVIFVVVRSCRKKSARPAAGVGDTGIEDANAVRGSASQGPLTEPWAEDSPPDQPPPA
SARSSVGEGELQYASLSFQMVKPWDSRGQEATDTEYSEIKIHR
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase S1 family, Kallikrein subfamily
Subcellular location
Secreted
Function May be involved in desquamation.
TTD ID
T11808
Uniprot ID
Q9Y337
DrugMap ID
TTULSEW
Ensemble ID
ENST00000336334.8
HGNC ID
HGNC:6366
ChEMBL ID
CHEMBL4447

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [1]
MPP-AC
 Probe Info  		N.A.  LDD0428  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Filaggrin (FLG) S100-fused protein family P20930
Protein MANBAL (MANBAL) UPF0239 family Q9NQG1

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid23849879c3 Small molecular drug D00LOL
Pmid25489658c4d Small molecular drug D07OQF

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.