Details of the Target

General Information of Target

Target ID LDTP13915
Target Name CDAN1-interacting nuclease 1 (CDIN1)
Gene Name CDIN1
Gene ID 84529
Synonyms
C15orf41; CDAN1-interacting nuclease 1; Protein HH114
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYD
FYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYM
LDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDET
SFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDA
RMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY
CISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQ
PKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS
Target Bioclass
Other
Subcellular location
Nucleus
Function Plays a role in erythroid cell differentiation.
Uniprot ID
Q9Y2V0
Ensemble ID
ENST00000338183.8
HGNC ID
HGNC:26929

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.V76A .
HT SNV: p.F32V .
HT115 SNV: p.R54I .
KP4 SNV: p.P116S .
LN229 Substitution: p.R26W .
NB1 Deletion: p.T114IfsTer8 .
SNU1 Insertion: p.N79KfsTer13 .
TOV21G SNV: p.A100D .
UACC257 SNV: p.H111Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C268(1.86); C277(1.86)  LDD0080  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C268(0.84); C277(0.84)  LDD0531  [1]
 LDCM0276  AC17 HCT 116 C268(0.69); C277(0.69)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C268(1.03); C277(1.03)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C268(1.07); C277(1.07)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C268(0.74); C277(0.74)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C268(1.48); C277(1.48)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C268(1.22); C277(1.22)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C268(0.85); C277(0.85)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C268(1.09); C277(1.09)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C268(1.18); C277(1.18)  LDD0601  [1]
 LDCM0290  AC3 HCT 116 C268(0.59); C277(0.59)  LDD0607  [1]
 LDCM0301  AC4 HCT 116 C268(0.62); C277(0.62)  LDD0618  [1]
 LDCM0312  AC5 HCT 116 C268(0.67); C277(0.67)  LDD0629  [1]
 LDCM0320  AC57 HCT 116 C268(0.86); C277(0.86)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C268(1.15); C277(1.15)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C268(1.14); C277(1.14)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C268(1.37); C277(1.37)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C268(0.98); C277(0.98)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C268(1.04); C277(1.04)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C268(1.06); C277(1.06)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C268(1.12); C277(1.12)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C268(1.08); C277(1.08)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C268(1.08); C277(1.08)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C268(1.09); C277(1.09)  LDD0648  [1]
 LDCM0367  CL1 HCT 116 C268(0.85); C277(0.85)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C268(0.61); C277(0.61)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C268(0.80); C277(0.80)  LDD0686  [1]
 LDCM0374  CL105 HCT 116 C268(1.16); C277(1.16)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C268(0.90); C277(0.90)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C268(0.88); C277(0.88)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C268(0.64); C277(0.64)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C268(0.93); C277(0.93)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C268(0.62); C277(0.62)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C268(0.97); C277(0.97)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C268(1.50); C277(1.50)  LDD0698  [1]
 LDCM0390  CL12 HCT 116 C268(0.55); C277(0.55)  LDD0707  [1]
 LDCM0396  CL125 HCT 116 C268(0.94); C277(0.94)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C268(1.28); C277(1.28)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C268(1.25); C277(1.25)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C268(0.92); C277(0.92)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C268(0.81); C277(0.81)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C268(0.73); C277(0.73)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C268(0.88); C277(0.88)  LDD0719  [1]
 LDCM0407  CL2 HCT 116 C268(0.87); C277(0.87)  LDD0724  [1]
 LDCM0418  CL3 HCT 116 C268(1.08); C277(1.08)  LDD0735  [1]
 LDCM0429  CL4 HCT 116 C268(0.72); C277(0.72)  LDD0746  [1]
 LDCM0440  CL5 HCT 116 C268(0.81); C277(0.81)  LDD0757  [1]
 LDCM0451  CL6 HCT 116 C268(0.81); C277(0.81)  LDD0768  [1]
 LDCM0462  CL7 HCT 116 C268(0.64); C277(0.64)  LDD0779  [1]
 LDCM0473  CL8 HCT 116 C268(1.30); C277(1.30)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C268(0.80); C277(0.80)  LDD0801  [1]
 LDCM0486  CL91 HCT 116 C268(0.99); C277(0.99)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C268(0.90); C277(0.90)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C268(0.57); C277(0.57)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C268(0.74); C277(0.74)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C268(0.85); C277(0.85)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C268(0.79); C277(0.79)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C268(0.83); C277(0.83)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C268(0.82); C277(0.82)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C268(0.86); C277(0.86)  LDD0811  [1]
 LDCM0022  KB02 HCT 116 C268(1.86); C277(1.86)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C268(1.38); C277(1.38)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C268(2.02); C277(2.02)  LDD0082  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.