Details of the Target

General Information of Target

Target ID LDTP13886
Target Name Syntaxin-binding protein 5-like (STXBP5L)
Gene Name STXBP5L
Gene ID 9515
Synonyms
KIAA1006; LLGL4; Syntaxin-binding protein 5-like; Lethal(2) giant larvae protein homolog 4; Tomosyn-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLHTNKYNANFVTFMEGK
DFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIE
MTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKES
QTESTNAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHN
LELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFL
HSFNIPMQLKIYNIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKEFQKESLS
MDLELNGLESGNGDEEAVDREPRRLSSRRSVLTSPVANGVNLDYDGLGKTCRSLPSLKKT
LAGDSSSDCSRGSHNGQVWDPQCAPRKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPT
GIEDEDALIADVKILLEELANSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKP
HTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRM
KQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEG
LLNEELPNCWECPKCYQEDSSEKAQKRKMEESDEEAVQAKVLRPLRSCDEPLTPPPHSPT
SMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNP
SGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRHSPRVLVQHC
PARTPQRGDEEGLGGEEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMS
VFRYLSRRELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLS
WTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIR
DLLTPPADKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQ
SSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLIYLRRIANVTLIDLRGCKQITRKACEHF
ISDLSINSLYCLSDEKLIQKIS
Target Bioclass
Other
Family
WD repeat L(2)GL family
Subcellular location
Cytoplasm
Function
Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth.
Uniprot ID
Q9Y2K9
Ensemble ID
ENST00000273666.10
HGNC ID
HGNC:30757

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C530(0.95); C609(0.92)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C530(0.95); C609(0.92)  LDD1507  [1]
 LDCM0270  AC15 HEK-293T C530(1.00)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C530(0.90); C609(0.86)  LDD1515  [1]
 LDCM0283  AC23 HEK-293T C530(0.98)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C530(0.91); C609(0.95)  LDD1524  [1]
 LDCM0292  AC31 HEK-293T C530(0.91)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C530(0.86); C609(0.99)  LDD1533  [1]
 LDCM0300  AC39 HEK-293T C530(0.92)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C530(0.92); C609(0.90)  LDD1542  [1]
 LDCM0309  AC47 HEK-293T C530(0.97)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C530(0.97); C609(1.03)  LDD1550  [1]
 LDCM0318  AC55 HEK-293T C530(0.99)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C530(1.03); C609(1.05)  LDD1559  [1]
 LDCM0327  AC63 HEK-293T C530(0.96)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C530(1.07)  LDD1568  [1]
 LDCM0356  AKOS034007680 HEK-293T C530(0.90); C609(0.95)  LDD1570  [1]
 LDCM0372  CL103 HEK-293T C530(0.92)  LDD1576  [1]
 LDCM0376  CL107 HEK-293T C530(0.90)  LDD1580  [1]
 LDCM0379  CL11 HEK-293T C530(1.02)  LDD1583  [1]
 LDCM0381  CL111 HEK-293T C530(0.90)  LDD1585  [1]
 LDCM0385  CL115 HEK-293T C530(0.89)  LDD1589  [1]
 LDCM0389  CL119 HEK-293T C530(0.97)  LDD1593  [1]
 LDCM0394  CL123 HEK-293T C530(0.94)  LDD1598  [1]
 LDCM0398  CL127 HEK-293T C530(1.15)  LDD1602  [1]
 LDCM0402  CL15 HEK-293T C530(0.93)  LDD1606  [1]
 LDCM0404  CL17 HEK-293T C530(0.88); C609(0.98)  LDD1608  [1]
 LDCM0411  CL23 HEK-293T C530(1.05)  LDD1615  [1]
 LDCM0415  CL27 HEK-293T C530(0.91)  LDD1619  [1]
 LDCM0417  CL29 HEK-293T C530(0.97); C609(0.90)  LDD1621  [1]
 LDCM0418  CL3 HEK-293T C530(0.94)  LDD1622  [1]
 LDCM0424  CL35 HEK-293T C530(1.12)  LDD1628  [1]
 LDCM0428  CL39 HEK-293T C530(0.87)  LDD1632  [1]
 LDCM0431  CL41 HEK-293T C530(0.91); C609(0.91)  LDD1635  [1]
 LDCM0437  CL47 HEK-293T C530(1.10)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C530(1.10); C609(0.91)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C530(0.99); C609(0.54)  LDD1647  [1]
 LDCM0450  CL59 HEK-293T C530(1.17)  LDD1653  [1]
 LDCM0455  CL63 HEK-293T C530(0.96)  LDD1658  [1]
 LDCM0457  CL65 HEK-293T C530(0.92); C609(1.07)  LDD1660  [1]
 LDCM0464  CL71 HEK-293T C530(1.19)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C530(1.06); C609(0.94)  LDD1673  [1]
 LDCM0477  CL83 HEK-293T C530(1.17)  LDD1680  [1]
 LDCM0481  CL87 HEK-293T C530(1.25)  LDD1684  [1]
 LDCM0483  CL89 HEK-293T C530(1.30); C609(1.03)  LDD1686  [1]
 LDCM0490  CL95 HEK-293T C530(1.25)  LDD1693  [1]
 LDCM0494  CL99 HEK-293T C530(0.97)  LDD1697  [1]
 LDCM0495  E2913 HEK-293T C530(0.87)  LDD1698  [1]
 LDCM0468  Fragment33 HEK-293T C530(0.96)  LDD1671  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402