Details of the Target

General Information of Target

Target ID LDTP13879
Target Name Protein-arginine deiminase type-2 (PADI2)
Gene Name PADI2
Gene ID 11240
Synonyms
KIAA0994; PAD2; PDI2; Protein-arginine deiminase type-2; EC 3.5.3.15; PAD-H19; Peptidylarginine deiminase II; Protein-arginine deiminase type II
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGTGGTGSPQASLEILAP
EDSQVLQQATRQEPQGQEHQGGENHLAENTLYRLCPQPSKGEELPTYEEAKAHSQYYAAQ
QAGTRPHAGDRDPRGAPGGSRRQDEALRELRHGHVRSLSERLLQLSLERNGARAPSHMSS
SHSFPQLARNQQGPPLRGPPAEGPESRGPPPQYPHVVLAHETTTAVTDPRYRARGSPHFQ
HAEVRILQAQVPPVFLQQQQQYQYLQQSQEHPPPPHPAALGHGPLSSLSPPAVEGPVSAQ
ASSATSGSAHLAQMEAVLRENARLQRDNERLQRELESSAEKAGRIEKLESEIQRLSEAHE
SLTRASSKREALEKTMRNKMDSEMRRLQDFNRDLRERLESANRRLASKTQEAQAGSQDMV
AKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRRAELLEQALGNAQGRAARAEEELRKKQ
AYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQAGAPGGSSGSGGS
PELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIR
HSPQPSPSSSFNEGLLTGGHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRRDPGKAIQG
SLRPAKSVPSVFAAAAAGTQGWQGLSSSERQTADAPARLTTDRAPTEEPVVTAPPAAHAK
HGSRDGSTQTEGPPDSTSTCLPPEPDSLLGCSSSQRAASLDSVATSRVQDLSDMVEILI
Target Bioclass
Enzyme
Family
Protein arginine deiminase family
Subcellular location
Cytoplasm
Function Catalyzes the deimination of arginine residues of proteins.
Uniprot ID
Q9Y2J8
Ensemble ID
ENST00000375481.1
HGNC ID
HGNC:18341
ChEMBL ID
CHEMBL1909487

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L489I .
CAL51 SNV: p.G421D .
HCT15 SNV: p.D576E .
IGROV1 SNV: p.A458V; p.H471R DBIA    Probe Info 
MDAMB453 SNV: p.E503D DBIA    Probe Info 
NCIH716 SNV: p.L518F .
NUGC3 SNV: p.T114I .
PF382 SNV: p.M299V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C647(1.09)  LDD3314  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0276  AC17 PaTu 8988t C338(1.13)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C338(1.38)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C338(1.09)  LDD1157  [2]
 LDCM0280  AC20 PaTu 8988t C338(1.06)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C338(1.00)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C338(1.08)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C338(1.72)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C338(1.65)  LDD1163  [2]
 LDCM0308  AC46 PaTu 8988t C338(0.94)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C338(1.12)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C338(1.06)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C338(1.56)  LDD1190  [2]
 LDCM0313  AC50 PaTu 8988t C338(1.40)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C338(0.39)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C338(1.16)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C338(1.36)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C338(1.62)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C338(1.27)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C338(1.36)  LDD1198  [2]
 LDCM0367  CL1 PaTu 8988t C338(1.26)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C338(1.54)  LDD1247  [2]
 LDCM0374  CL105 PaTu 8988t C338(1.36)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C338(1.36)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C338(1.05)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C338(1.30)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C338(1.16)  LDD1257  [2]
 LDCM0379  CL11 PaTu 8988t C338(1.08)  LDD1258  [2]
 LDCM0380  CL110 PaTu 8988t C338(1.35)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C338(1.49)  LDD1260  [2]
 LDCM0390  CL12 PaTu 8988t C338(1.17)  LDD1269  [2]
 LDCM0392  CL121 PaTu 8988t C338(1.23)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C338(1.29)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C338(1.17)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C338(1.53)  LDD1274  [2]
 LDCM0400  CL13 PaTu 8988t C338(1.66)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C338(1.82)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C338(2.18)  LDD1281  [2]
 LDCM0407  CL2 PaTu 8988t C338(1.29)  LDD1286  [2]
 LDCM0418  CL3 PaTu 8988t C338(1.62)  LDD1297  [2]
 LDCM0420  CL31 PaTu 8988t C338(0.98)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C338(1.39)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C338(1.53)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C338(1.04)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C338(1.19)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C338(0.83)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C338(1.46)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C338(1.14)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C338(1.12)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C338(0.98)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C338(1.25)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C338(1.65)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C338(1.62)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C338(1.58)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C338(1.25)  LDD1314  [2]
 LDCM0440  CL5 PaTu 8988t C338(1.67)  LDD1319  [2]
 LDCM0451  CL6 PaTu 8988t C338(2.52)  LDD1330  [2]
 LDCM0453  CL61 PaTu 8988t C338(1.01)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C338(0.78)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C338(0.83)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C338(0.90)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C338(0.98)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C338(1.02)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C338(1.12)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C338(1.10)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C338(1.05)  LDD1340  [2]
 LDCM0462  CL7 PaTu 8988t C338(1.46)  LDD1341  [2]
 LDCM0463  CL70 PaTu 8988t C338(0.89)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C338(0.78)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C338(0.68)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C338(1.00)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C338(0.82)  LDD1346  [2]
 LDCM0473  CL8 PaTu 8988t C338(1.21)  LDD1352  [2]
 LDCM0484  CL9 PaTu 8988t C338(1.86)  LDD1363  [2]
 LDCM0468  Fragment33 PaTu 8988t C338(1.04)  LDD1347  [2]
 LDCM0427  Fragment51 PaTu 8988t C338(1.40)  LDD1306  [2]
 LDCM0022  KB02 769-P C155(1.04); C647(1.45)  LDD2246  [1]
 LDCM0023  KB03 769-P C647(1.96)  LDD2663  [1]
 LDCM0024  KB05 IGR37 C647(1.09)  LDD3314  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Citrulline Small molecular drug DB00155

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.