Details of the Target

General Information of Target

Target ID LDTP13742
Target Name MAPK/MAK/MRK overlapping kinase (MOK)
Gene Name MOK
Gene ID 5891
Synonyms
RAGE; RAGE1; MAPK/MAK/MRK overlapping kinase; EC 2.7.11.22; MOK protein kinase; Renal tumor antigen 1; RAGE-1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV
MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM
GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT
GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV
AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI
GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV
VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP
SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQR
MYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR
ADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGS
LEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR
GLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK
TLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSP
SLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA
PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRE
LRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPA
SVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
Subcellular location
Cytoplasm
Function Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner.
Uniprot ID
Q9UQ07
Ensemble ID
ENST00000361847.7
HGNC ID
HGNC:9833
ChEMBL ID
CHEMBL4295983

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.F146V .
HCC1419 SNV: p.S361L .
HCT15 SNV: p.P403H .
HEC1B SNV: p.P308H .
KMCH1 SNV: p.E171Ter; p.A404S .
PATU8988T SNV: p.P221A DBIA    Probe Info 
SW403 SNV: p.R384I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C32(0.64)  LDD1109  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0230  AC113 PaTu 8988t C32(0.64)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C32(0.75)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C32(0.59)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C32(0.61)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C32(0.63)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C32(0.63)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C32(0.77)  LDD1115  [1]
 LDCM0238  AC120 PaTu 8988t C32(0.57)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C32(0.73)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C32(0.52)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C32(0.57)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C32(0.77)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C32(0.78)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C32(1.31)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C32(0.70)  LDD1124  [1]
 LDCM0263  AC143 PaTu 8988t C32(1.12)  LDD1142  [1]
 LDCM0264  AC144 PaTu 8988t C32(0.92)  LDD1143  [1]
 LDCM0265  AC145 PaTu 8988t C32(1.02)  LDD1144  [1]
 LDCM0266  AC146 PaTu 8988t C32(0.96)  LDD1145  [1]
 LDCM0267  AC147 PaTu 8988t C32(1.55)  LDD1146  [1]
 LDCM0268  AC148 PaTu 8988t C32(1.19)  LDD1147  [1]
 LDCM0269  AC149 PaTu 8988t C32(1.39)  LDD1148  [1]
 LDCM0271  AC150 PaTu 8988t C32(0.90)  LDD1150  [1]
 LDCM0272  AC151 PaTu 8988t C32(1.08)  LDD1151  [1]
 LDCM0273  AC152 PaTu 8988t C32(1.03)  LDD1152  [1]
 LDCM0274  AC153 PaTu 8988t C32(1.36)  LDD1153  [1]
 LDCM0621  AC154 PaTu 8988t C32(1.17)  LDD2166  [1]
 LDCM0622  AC155 PaTu 8988t C32(1.24)  LDD2167  [1]
 LDCM0623  AC156 PaTu 8988t C32(1.20)  LDD2168  [1]
 LDCM0624  AC157 PaTu 8988t C32(1.09)  LDD2169  [1]
 LDCM0276  AC17 PaTu 8988t C32(1.12)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C32(1.15)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C32(1.31)  LDD1157  [1]
 LDCM0280  AC20 PaTu 8988t C32(0.93)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C32(1.03)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C32(1.46)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C32(1.58)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C32(1.15)  LDD1163  [1]
 LDCM0332  AC68 PaTu 8988t C32(0.62)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C32(0.68)  LDD1212  [1]
 LDCM0335  AC70 PaTu 8988t C32(0.80)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C32(0.55)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C32(0.59)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C32(0.66)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C32(0.60)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C32(0.64)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C32(0.74)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C32(0.59)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C32(0.52)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C32(0.54)  LDD1223  [1]
 LDCM0346  AC80 PaTu 8988t C32(0.48)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C32(0.66)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C32(0.68)  LDD1227  [1]
 LDCM0374  CL105 PaTu 8988t C32(1.42)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C32(0.94)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C32(1.09)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C32(1.41)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C32(1.40)  LDD1257  [1]
 LDCM0380  CL110 PaTu 8988t C32(1.35)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C32(1.37)  LDD1260  [1]
 LDCM0403  CL16 PaTu 8988t C32(1.20)  LDD1282  [1]
 LDCM0404  CL17 PaTu 8988t C32(1.62)  LDD1283  [1]
 LDCM0405  CL18 PaTu 8988t C32(1.27)  LDD1284  [1]
 LDCM0406  CL19 PaTu 8988t C32(1.05)  LDD1285  [1]
 LDCM0408  CL20 PaTu 8988t C32(1.09)  LDD1287  [1]
 LDCM0409  CL21 PaTu 8988t C32(2.08)  LDD1288  [1]
 LDCM0410  CL22 PaTu 8988t C32(1.56)  LDD1289  [1]
 LDCM0411  CL23 PaTu 8988t C32(1.07)  LDD1290  [1]
 LDCM0412  CL24 PaTu 8988t C32(1.23)  LDD1291  [1]
 LDCM0413  CL25 PaTu 8988t C32(1.48)  LDD1292  [1]
 LDCM0414  CL26 PaTu 8988t C32(1.19)  LDD1293  [1]
 LDCM0415  CL27 PaTu 8988t C32(1.46)  LDD1294  [1]
 LDCM0416  CL28 PaTu 8988t C32(1.39)  LDD1295  [1]
 LDCM0417  CL29 PaTu 8988t C32(1.06)  LDD1296  [1]
 LDCM0419  CL30 PaTu 8988t C32(1.26)  LDD1298  [1]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.