Details of the Target

General Information of Target

Target ID LDTP13617
Target Name Calpain-11 (CAPN11)
Gene Name CAPN11
Gene ID 11131
Synonyms
Calpain-11; EC 3.4.22.-; Calcium-activated neutral proteinase 11; CANP 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHCHAELRLSSPGQLKAARRRYKTFMIDEILSKETCDYFEKLSLYSVCPSLVVRPKPLHS
CTGSPSLRAYPLLSVITRQPTVISHLVPATPGIAQALSCHQVTEAVSAEAPGGEALASSE
SETEQPTPRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLGLTQLQVKTW
YQNRRMKWKKMVLKGGQEAPTKPKGRPKKNSIPTSEEIEAEEKMNSQAQGQEQLEPSQGQ
EELCEAQEPKARDVPLEMAEPPDPPQELPIPSSEPPPLS
Target Bioclass
Enzyme
Family
Peptidase C2 family
Subcellular location
Cytoplasmic vesicle, secretory vesicle, acrosome
Function Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.
Uniprot ID
Q9UMQ6
Ensemble ID
ENST00000398776.2
HGNC ID
HGNC:1478

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C615(0.95)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C615(0.95)  LDD1507  [1]
 LDCM0270  AC15 HEK-293T C615(1.06)  LDD1513  [1]
 LDCM0276  AC17 HEK-293T C615(0.99)  LDD1515  [1]
 LDCM0281  AC21 HEK-293T C615(1.04)  LDD1520  [1]
 LDCM0283  AC23 HEK-293T C615(0.93)  LDD1522  [1]
 LDCM0285  AC25 HEK-293T C615(0.95)  LDD1524  [1]
 LDCM0289  AC29 HEK-293T C615(0.97)  LDD1528  [1]
 LDCM0292  AC31 HEK-293T C615(1.04)  LDD1531  [1]
 LDCM0294  AC33 HEK-293T C615(1.02)  LDD1533  [1]
 LDCM0298  AC37 HEK-293T C615(1.10)  LDD1537  [1]
 LDCM0300  AC39 HEK-293T C615(1.00)  LDD1539  [1]
 LDCM0303  AC41 HEK-293T C615(1.10)  LDD1542  [1]
 LDCM0307  AC45 HEK-293T C615(0.99)  LDD1546  [1]
 LDCM0309  AC47 HEK-293T C615(1.00)  LDD1548  [1]
 LDCM0311  AC49 HEK-293T C615(0.99)  LDD1550  [1]
 LDCM0312  AC5 HEK-293T C615(1.00)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C615(1.02)  LDD1555  [1]
 LDCM0318  AC55 HEK-293T C615(1.01)  LDD1557  [1]
 LDCM0320  AC57 HEK-293T C615(0.91)  LDD1559  [1]
 LDCM0325  AC61 HEK-293T C615(1.12)  LDD1564  [1]
 LDCM0327  AC63 HEK-293T C615(1.01)  LDD1566  [1]
 LDCM0334  AC7 HEK-293T C615(1.04)  LDD1568  [1]
 LDCM0248  AKOS034007472 HEK-293T C615(1.07)  LDD1511  [1]
 LDCM0356  AKOS034007680 HEK-293T C615(1.01)  LDD1570  [1]
 LDCM0379  CL11 HEK-293T C615(1.17)  LDD1583  [1]
 LDCM0404  CL17 HEK-293T C615(0.92)  LDD1608  [1]
 LDCM0409  CL21 HEK-293T C615(1.26)  LDD1613  [1]
 LDCM0411  CL23 HEK-293T C615(1.28)  LDD1615  [1]
 LDCM0417  CL29 HEK-293T C615(1.21)  LDD1621  [1]
 LDCM0422  CL33 HEK-293T C615(1.12)  LDD1626  [1]
 LDCM0424  CL35 HEK-293T C615(1.37)  LDD1628  [1]
 LDCM0431  CL41 HEK-293T C615(1.06)  LDD1635  [1]
 LDCM0435  CL45 HEK-293T C615(1.21)  LDD1639  [1]
 LDCM0437  CL47 HEK-293T C615(1.41)  LDD1641  [1]
 LDCM0440  CL5 HEK-293T C615(1.02)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C615(1.02)  LDD1647  [1]
 LDCM0448  CL57 HEK-293T C615(1.35)  LDD1651  [1]
 LDCM0450  CL59 HEK-293T C615(1.40)  LDD1653  [1]
 LDCM0457  CL65 HEK-293T C615(1.08)  LDD1660  [1]
 LDCM0461  CL69 HEK-293T C615(1.28)  LDD1664  [1]
 LDCM0464  CL71 HEK-293T C615(1.33)  LDD1667  [1]
 LDCM0470  CL77 HEK-293T C615(1.06)  LDD1673  [1]
 LDCM0475  CL81 HEK-293T C615(1.25)  LDD1678  [1]
 LDCM0477  CL83 HEK-293T C615(1.20)  LDD1680  [1]
 LDCM0483  CL89 HEK-293T C615(1.07)  LDD1686  [1]
 LDCM0484  CL9 HEK-293T C615(1.24)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C615(1.16)  LDD1691  [1]
 LDCM0490  CL95 HEK-293T C615(1.12)  LDD1693  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402