Details of the Target

General Information of Target

Target ID LDTP13554
Target Name Protein BCAP (ODF2L)
Gene Name ODF2L
Gene ID 57489
Synonyms
BCAP; KIAA1229; Protein BCAP; Basal body centriole-associated protein; Outer dense fiber protein 2-like; ODF2-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVGRGVPLCAAQPAVAEGGPAREPPPLLEVSPRKRLPAGPDQDPCGSRPAPEGAGAGPEQ
GHSAGGGGWCRHCHTKLVELKRQAWKLVSGPGTTLRDPCLSALLLDKLPAPGALPACRPE
AERRCDVCATHLQQLTREAMHLLQAPASHEDLDAPHGGPSLAPPSTTTSSRDTPGPAGPA
GRQPGRAGPDRTKGLAWSPGPSVQVSVAPAGLGGALSTVTIQAQQCLEGMWSVSRVNSFL
PPACLAEAAVAAVAVADTVRECPPVAGPDGLSKAWGRGGVCTSALVTPTPGSVGGSTGPS
AAASFFIRAMQKLSLASKRKKPHPPPPPATRGTSTYPTDFSGVLQLWPPPAPPCLLRAAS
KTKDNPGSIGKVKVMLRIWPAQGAQRSAEAMSFLKVDPRKKQVILYDPAAGPPGSAGPRR
AATAAVPKMFAFDAVFPQDSEQAEVCSGTVADVLQSVVSGADGCIFSFGHMSLGKSYTMI
GKDSSPQSLGIVPCAISWLFRLIEERRERTGTRFSVRVSAVEVCGRDQSLRDLLAEVAPG
SLQDTQSPGVYLREDPVCGAQLQNQSELRAPTAEKAAFYLDAALAARSTSRAGCGEDARR
SSHMLFTLHVYQYRMEKCGRGGMSGGRSRLHLIDLGSCEAAAGRAGEAAGGPLCLSLSAL
GSVILALVNGAKHVPYRDHRLTMLLRESLATAGCRTTMIAHVSDAPAQHAETLSTVQLAA
RIHRLRRKKAKYASSSSGGESSCEEGRARRPPHLRPFHPRTVALDPDRTPPCLPGDPDYS
SSSEQSCDTVIYVGPGGAALSDRELTDNEGPPDFVPIIPALSRHRPSKGPRDADHFRCST
FAELQERLECMDGNEGPSGGPGGTDGAQASPARGGRKPSPPEAASPRKAVGTPMAASTPR
GSSGPDTHQGTPEPCKAIVWGDQREDSSAWPELLVPEKAAVSGGRRPLPSPAPPPPQLLE
ACRAPEEPGGGGTDGVARTPPVGMSGQVAGSPMLPGATCPRLAAGSRCPERGLLTTTVTL
QRPVELNGEDELVFTVVEELSLGALAGAGRPTSLASFDSDCSLRALASGSRPVSIISSIN
DEFDAYTSQAPEGGPLEGAAWAGSSHGSSISSWLSEVSVCTADSRDPTPQPRFSPDSLAG
LDPGGPPALDGSLGDGSSGFLGPDRPDSPGPTWGPCPGEVAAVAPSRPGREPQAGPSRWA
SAAQTIHSSLPRKPRTASATTRVGCARLGQSPPGRGGLFEDPWLLRVGECDTQAASAGRA
PSPTLGSPRLPEAQVMLACAQRVVDGCEVAARAARRPEAVARIPPLRRGATTLGVTTPAV
SWGDAPTEVVACSGSLKASPTSKKGLAPKAGFLPRPSGAAPPAPPTRKSSLEQRSSPASA
PPHAVNPARVGAAAVLRGEEEPRPSSRADHSVPRATSSLKARASKVEAAHRLAGHASLER
YEGLAHSSSKGREAPGRPPRAVPKLGVPPSSPTHGPAPACRSGAAKAVGAPKPPVGGGKG
RGLVAGGSRALGPSVKLSTASVTGRSPGGPVAGPRAAPRAGPSVGAKAGRGTVMGTKQAL
RAAHSRVHELSASGAPGRGGSSWGSADSDSGHDSGVNVGEERPPTGPALPSPYSKVTAPR
RPQRYSSGHGSDNSSVLSGELPPAMGRTALFHHSGGSSGYESLRRDSEATGSASSAPDSM
SESGAASPGARTRSLKSPKKRATGLQRRRLIPAPLPDTTALGRKPSLPGQWVDLPPPLAG
SLKEPFEIKVYEIDDVERLQRPRPTPREAPTQGLACVSTRLRLAERRQQRLREVQAKHKH
LCEELAETQGRLMLEPGRWLEQFEVDPELEPESAEYLAALERATAALEQCVNLCKAHVMM
VTCFDISVAASAAIPGPQEVDV
Target Bioclass
Other
Family
ODF2 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite
Function Acts as a suppressor of ciliogenesis, specifically, the initiation of ciliogenesis.
Uniprot ID
Q9ULJ1
Ensemble ID
ENST00000294678.6
HGNC ID
HGNC:29225

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K47(8.33)  LDD0274  [1]
DBIA
 Probe Info  		C493(1.37)  LDD3427  [2]
IA-alkyne
 Probe Info  		C433(1.33)  LDD2182  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C433(0.75)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C433(1.95)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C433(6.84)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C433(1.32)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C433(0.97)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C433(1.47)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C433(1.18)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C433(1.01)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C433(1.42)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C433(1.00)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C433(0.81)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C433(1.25)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C433(1.24)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C433(2.06)  LDD2201  [3]
 LDCM0468  Fragment33 Ramos C433(1.06)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C433(0.95)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C433(0.93)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C433(1.22)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C433(1.49)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C433(0.98)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C433(1.57)  LDD2188  [3]
 LDCM0022  KB02 Ramos C433(1.33)  LDD2182  [3]
 LDCM0023  KB03 Ramos C433(1.05)  LDD2183  [3]
 LDCM0024  KB05 SK-MEL-28 C493(1.37)  LDD3427  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578