Details of the Target

General Information of Target

Target ID LDTP13495
Target Name Myosin-2 (MYH2)
Gene Name MYH2
Gene ID 4620
Synonyms
MYHSA2; Myosin-2; Myosin heavy chain 2; Myosin heavy chain 2a; MyHC-2a; Myosin heavy chain IIa; MyHC-IIa; Myosin heavy chain, skeletal muscle, adult 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPSLPHSHRVMLDSVTHSTFLPNASFCDPLMSWTDLFSNEEYYPAFEHQTACDSYWTSVH
PEYWTKRHVWEWLQFCCDQYKLDTNCISFCNFNISGLQLCSMTQEEFVEAAGLCGEYLYF
ILQNIRTQGYSFFNDAEESKATIKDYADSNCLKTSGIKSQDCHSHSRTSLQSSHLWEFVR
DLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTG
ILERVDRRLVYKFGKNAHGWQEDKL
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Subcellular location
Cytoplasm, myofibril
Function Muscle contraction. Required for cytoskeleton organization.
TTD ID
T90071
Uniprot ID
Q9UKX2
DrugMap ID
TTBIL13
Ensemble ID
ENST00000245503.10
HGNC ID
HGNC:7572
ChEMBL ID
CHEMBL4295980

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.K1099N .
COLO320 SNV: p.T1659N .
COLO792 SNV: p.P544S; p.E1269K; p.Q1428E .
DU145 SNV: p.A384D .
EGI1 SNV: p.L1005I .
ETK1 SNV: p.S1419F; p.I1490V .
GB1 SNV: p.M360T .
HCT15 SNV: p.E1861G .
HT115 SNV: p.E45Ter; p.K207N; p.K437N .
HT1197 SNV: p.L398V .
IGR1 SNV: p.T547I .
IPC298 SNV: p.S1342F .
JEKO1 SNV: p.I1490R .
JURKAT SNV: p.V383I .
KMCH1 SNV: p.E881Ter .
KURAMOCHI SNV: p.A101V .
LNCaP clone FGC SNV: p.V730A .
LS180 SNV: p.L776R .
LU65 SNV: p.L1436V .
MCC13 SNV: p.R1056K .
MELJUSO SNV: p.E1911K .
MEWO SNV: p.P737S .
MOLT4 SNV: p.D1038Y .
NCIH1666 SNV: p.V653L .
NCIH1944 SNV: p.A14S; p.R1619M .
NCIH2170 SNV: p.E1890Q .
NCIH2172 SNV: p.D160E; p.C523S .
NCIH2286 SNV: p.K847N .
NCIH358 SNV: p.Q1688R .
PEO1 Deletion: p.E510_F516del .
SH4 SNV: p.A1133S .
SKMEL2 SNV: p.T767I .
SKMEL28 SNV: p.A1446V .
SKN SNV: p.M988I .
SSP25 SNV: p.S1419F; p.I1490V .
T98G SNV: p.L526P .
TOV21G Deletion: p.S37CfsTer28 .
UACC257 SNV: p.G1284R .
WM793 SNV: p.V1928M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TPP-AC
 Probe Info  		N.A.  LDD0427  [1]

References

1 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.