Details of the Target

General Information of Target

Target ID LDTP13413
Target Name Heat shock protein beta-8 (HSPB8)
Gene Name HSPB8
Gene ID 26353
Synonyms
CRYAC; E2IG1; HSP22; Heat shock protein beta-8; HspB8; Alpha-crystallin C chain; E2-induced gene 1 protein; Protein kinase H11; Small stress protein-like protein HSP22
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAVVVAEGDSDSRPGQELLVAWNTVSTGLVPPAALGLVSSRTSGAVPPKEEELRAAVE
VLRGHGLHSVLEEWFVEVLQNDLQANISPEFWNAISQCENSADEPQCLLLLLDAFGLLES
RLDPYLRSLELLEKWTRLGLLMGTGAQGLREEVHTMLRGVLFFSTPRTFQEMIQRLYGCF
LRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCSSDKQQCWCRQALEQF
HQLSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWL
GKVFLQDGPARPASPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIVRDFPDSRPAIED
LKYCLERTDQRQQLLVSLKAALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVA
CEPIRRYLRTREDTVRQIVAGLTGDSDGTGDLAVELSKTDPASLETGQDSEDDSGEPEDW
VPDPVDADPGKSSSKRRSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIR
NVELLKLRFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEF
WPPFKDEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVT
PVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWLQQGVLREEPPGTFSVIEEER
PQDRDNMVLIDSDDESDSGMASQADQKEEELLLFWTYIQAMLTNLESLSLDRIYNMLRMF
VVTGPALAEIDLQELQGYLQKKVRDQQLVYSAGVYRLPKNCS
Target Type
Literature-reported
Target Bioclass
Other
Family
Small heat shock protein (HSP20) family
Subcellular location
Cytoplasm
Function Displays temperature-dependent chaperone activity.
TTD ID
T35161
Uniprot ID
Q9UJY1
DrugMap ID
TTY0OJN
Ensemble ID
ENST00000281938.7
HGNC ID
HGNC:30171

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C99(1.39)  LDD3314  [1]
5E-2FA
 Probe Info  		N.A.  LDD2235  [2]
m-APA
 Probe Info  		N.A.  LDD2231  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [3]
NAIA_5
 Probe Info  		C10(0.00); C99(0.00)  LDD2224  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [3]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C99(1.16)  LDD1512  [5]
 LDCM0282  AC22 HEK-293T C99(1.19)  LDD1521  [5]
 LDCM0291  AC30 HEK-293T C99(1.03)  LDD1530  [5]
 LDCM0299  AC38 HEK-293T C99(1.26)  LDD1538  [5]
 LDCM0308  AC46 HEK-293T C99(1.19)  LDD1547  [5]
 LDCM0317  AC54 HEK-293T C99(1.14)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C99(1.13)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C99(1.25)  LDD1565  [5]
 LDCM0632  CL-Sc Hep-G2 C10(1.22); C99(0.59)  LDD2227  [4]
 LDCM0368  CL10 HEK-293T C99(0.74)  LDD1572  [5]
 LDCM0410  CL22 HEK-293T C99(1.12)  LDD1614  [5]
 LDCM0423  CL34 HEK-293T C99(0.99)  LDD1627  [5]
 LDCM0436  CL46 HEK-293T C99(0.96)  LDD1640  [5]
 LDCM0449  CL58 HEK-293T C99(1.01)  LDD1652  [5]
 LDCM0463  CL70 HEK-293T C99(1.08)  LDD1666  [5]
 LDCM0476  CL82 HEK-293T C99(0.96)  LDD1679  [5]
 LDCM0489  CL94 HEK-293T C99(0.91)  LDD1692  [5]
 LDCM0022  KB02 HEK-293T C99(1.03)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C99(0.98)  LDD1497  [5]
 LDCM0024  KB05 IGR37 C99(1.39)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Monocarboxylate transporter 6 (SLC16A5) Monocarboxylate porter (TC 2.A.1.13) family O15375
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional regulator QRICH1 (QRICH1) . Q2TAL8
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Myeloid leukemia factor 2 (MLF2) MLF family Q15773
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Heat shock protein beta-2 (HSPB2) Small heat shock protein (HSP20) family Q16082
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
Heat shock protein beta-8 (HSPB8) Small heat shock protein (HSP20) family Q9UJY1
BAG family molecular chaperone regulator 3 (BAG3) . O95817
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Suppressor of cytokine signaling 7 (SOCS7) . O14512

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402