Details of the Target

General Information of Target

Target ID LDTP13315
Target Name Fasciculation and elongation protein zeta-2 (FEZ2)
Gene Name FEZ2
Gene ID 9637
Synonyms
Fasciculation and elongation protein zeta-2; Zygin II; Zygin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVVLSVPAEVTVILLDIEGTTTPIAFVKDILFPYIEENVKEYLQTHWEEEECQQDVSLLR
KQAEEDAHLDGAVPIPAASGNGVDDLQQMIQAVVDNVCWQMSLDRKTTALKQLQGHMWRA
AFTAGRMKAEFFADVVPAVRKWREAGMKVYIYSSGSVEAQKLLFGHSTEGDILELVDGHF
DTKIGHKVESESYRKIADSIGCSTNNILFLTDVTREASAAEEADVHVAVVVRPGNAGLTD
DEKTYYSLITSFSELYLPSST
Target Bioclass
Other
Family
Zygin family
Function Involved in axonal outgrowth and fasciculation.
Uniprot ID
Q9UHY8
Ensemble ID
ENST00000379245.8
HGNC ID
HGNC:3660

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 Deletion: p.Y11Ter .
HCT116 Deletion: p.N285MfsTer19 .
LS180 SNV: p.L60M .
MOLT4 SNV: p.K269E .
NCIH2172 SNV: p.S205C .
OVK18 SNV: p.W7Ter .
RH30 SNV: p.P158A .
TGBC1TKB SNV: p.S317C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C61(1.86)  LDD3413  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C61(0.83)  LDD1512  [5]
 LDCM0282  AC22 HEK-293T C61(0.79)  LDD1521  [5]
 LDCM0291  AC30 HEK-293T C61(0.92)  LDD1530  [5]
 LDCM0299  AC38 HEK-293T C61(0.85)  LDD1538  [5]
 LDCM0308  AC46 HEK-293T C61(1.00)  LDD1547  [5]
 LDCM0317  AC54 HEK-293T C61(1.07)  LDD1556  [5]
 LDCM0323  AC6 HEK-293T C61(0.99)  LDD1562  [5]
 LDCM0326  AC62 HEK-293T C61(1.03)  LDD1565  [5]
 LDCM0368  CL10 HEK-293T C61(0.82)  LDD1572  [5]
 LDCM0410  CL22 HEK-293T C61(0.72)  LDD1614  [5]
 LDCM0423  CL34 HEK-293T C61(0.67)  LDD1627  [5]
 LDCM0436  CL46 HEK-293T C61(0.76)  LDD1640  [5]
 LDCM0449  CL58 HEK-293T C61(0.76)  LDD1652  [5]
 LDCM0463  CL70 HEK-293T C61(0.88)  LDD1666  [5]
 LDCM0476  CL82 HEK-293T C61(0.85)  LDD1679  [5]
 LDCM0489  CL94 HEK-293T C61(0.80)  LDD1692  [5]
 LDCM0022  KB02 IPC-298 C61(1.71)  LDD2400  [1]
 LDCM0023  KB03 IPC-298 C61(2.05)  LDD2817  [1]
 LDCM0024  KB05 RVH-421 C61(1.86)  LDD3413  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC17 (ZDHHC17) DHHC palmitoyltransferase family Q8IUH5
Serine/threonine-protein kinase Nek1 (NEK1) NEK Ser/Thr protein kinase family Q96PY6
Serine/threonine-protein kinase PINK1, mitochondrial (PINK1) Ser/Thr protein kinase family Q9BXM7
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transthyretin (TTR) Transthyretin family P02766
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Survival motor neuron protein (SMN1; SMN2) SMN family Q16637

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402