Details of the Target

General Information of Target

Target ID LDTP13209
Target Name Zinc finger and BTB domain-containing protein 47 (ZBTB47)
Gene Name ZBTB47
Gene ID 92999
Synonyms
KIAA1190; ZNF651; Zinc finger and BTB domain-containing protein 47; Zinc finger protein 651
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGHLLSKEPRNRPSQKRPRCCSWCRRRRPLLRLPRRTPAKVPPQPAAPRSRDCFFRGPCM
LCFIVHSPGAPAPAGPEEEPPLSPPPRDGAYAAASSSQHLARRYAALAAEDCAAAARRFL
LSSAAAAAAAAASASSPASCCKELGLAAAAAWEQQGRSLFLASLGPVRFLGPPAAVQLFR
GPTPSPAELPTPPEMVCKRKGAGVPACTPCKQPRCGGGGCGGGGGGGGGGGPAGGGASPP
RPPDAGCCQAPEQPPQPLCPPPSSPTSEGAPTEAGGDAVRAGGTAPLSAQQQHECGDADC
RESPENPCDCHREPPPETPDINQLPPSILLKIFSNLSLDERCLSASLVCKYWRDLCLDFQ
FWKQLDLSSRQQVTDELLEKIASRSQNIIEINISDCRSMSDNGVCVLAFKCPGLLRYTAY
RCKQLSDTSIIAVASHCPLLQKVHVGNQDKLTDEGLKQLGSKCRELKDIHFGQCYKISDE
GMIVIAKGCLKLQRIYMQENKLVTDQSVKAFAEHCPELQYVGFMGCSVTSKGVIHLTKLR
NLSSLDLRHITELDNETVMEIVKRCKNLSSLNLCLNWIINDRCVEVIAKEGQNLKELYLV
SCKITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSSKSLRYLGLMRCDKVNEVT
VEQLVQQYPHITFSTVLQDCKRTLERAYQMGWTPNMSAASS
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9UFB7
Ensemble ID
ENST00000232974.11
HGNC ID
HGNC:26955

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.R3L .
CAL51 SNV: p.A83V .
HCC1419 SNV: p.R536C .
HCT15 SNV: p.H626R .
HEC1 SNV: p.E635K .
HEC1B SNV: p.E635K .
IGROV1 SNV: p.H246Y .
LS513 Deletion: p.R403_P404delinsT .
MEWO SNV: p.E278V .
MFE319 SNV: p.Q359H .
MOLT4 SNV: p.A369T .
RKO SNV: p.E326G; p.R592W .
SUPT1 SNV: p.S26N .
TCCSUP SNV: p.R644Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C208(1.04)  LDD1512  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C208(1.04)  LDD1512  [1]
 LDCM0282  AC22 HEK-293T C208(1.00)  LDD1521  [1]
 LDCM0291  AC30 HEK-293T C208(1.03)  LDD1530  [1]
 LDCM0299  AC38 HEK-293T C208(1.01)  LDD1538  [1]
 LDCM0308  AC46 HEK-293T C208(1.04)  LDD1547  [1]
 LDCM0317  AC54 HEK-293T C208(0.90)  LDD1556  [1]
 LDCM0323  AC6 HEK-293T C208(0.97)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C208(1.19)  LDD1565  [1]
 LDCM0367  CL1 HEK-293T C208(1.04)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C208(0.93)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C208(0.97)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C208(0.98)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C208(0.91)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C208(0.92)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C208(0.91)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C208(1.05)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C208(0.99)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C208(1.03)  LDD1604  [1]
 LDCM0410  CL22 HEK-293T C208(1.03)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C208(1.04)  LDD1617  [1]
 LDCM0423  CL34 HEK-293T C208(0.95)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C208(1.10)  LDD1630  [1]
 LDCM0436  CL46 HEK-293T C208(1.00)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C208(0.99)  LDD1643  [1]
 LDCM0449  CL58 HEK-293T C208(0.97)  LDD1652  [1]
 LDCM0453  CL61 HEK-293T C208(0.90)  LDD1656  [1]
 LDCM0463  CL70 HEK-293T C208(1.21)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C208(1.03)  LDD1669  [1]
 LDCM0476  CL82 HEK-293T C208(0.90)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C208(0.96)  LDD1682  [1]
 LDCM0489  CL94 HEK-293T C208(0.91)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C208(0.89)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402