Details of the Target

General Information of Target

Target ID LDTP13046
Target Name Zinc finger protein 319 (ZNF319)
Gene Name ZNF319
Gene ID 57567
Synonyms
KIAA1388; Zinc finger protein 319
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9P2F9
Ensemble ID
ENST00000299237.3
HGNC ID
HGNC:13644

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C307(1.39)  LDD3314  [1]
W1
 Probe Info  		D500(0.00); Y497(0.00)  LDD0236  [2]
HHS-465
 Probe Info  		K228(0.00); K231(0.00); Y230(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C289(0.72)  LDD1508  [4]
 LDCM0237  AC12 HEK-293T C289(1.05)  LDD1510  [4]
 LDCM0277  AC18 HEK-293T C289(1.07)  LDD1516  [4]
 LDCM0279  AC2 HEK-293T C289(0.81)  LDD1518  [4]
 LDCM0280  AC20 HEK-293T C289(1.21)  LDD1519  [4]
 LDCM0286  AC26 HEK-293T C289(0.78)  LDD1525  [4]
 LDCM0288  AC28 HEK-293T C289(1.04)  LDD1527  [4]
 LDCM0295  AC34 HEK-293T C289(0.92)  LDD1534  [4]
 LDCM0297  AC36 HEK-293T C289(1.50)  LDD1536  [4]
 LDCM0301  AC4 HEK-293T C289(1.01)  LDD1540  [4]
 LDCM0304  AC42 HEK-293T C289(0.76)  LDD1543  [4]
 LDCM0306  AC44 HEK-293T C289(1.30)  LDD1545  [4]
 LDCM0313  AC50 HEK-293T C289(0.75)  LDD1552  [4]
 LDCM0315  AC52 HEK-293T C289(1.14)  LDD1554  [4]
 LDCM0321  AC58 HEK-293T C289(0.91)  LDD1560  [4]
 LDCM0324  AC60 HEK-293T C289(1.08)  LDD1563  [4]
 LDCM0371  CL102 HEK-293T C289(1.02)  LDD1575  [4]
 LDCM0375  CL106 HEK-293T C289(1.33)  LDD1579  [4]
 LDCM0380  CL110 HEK-293T C289(1.06)  LDD1584  [4]
 LDCM0384  CL114 HEK-293T C289(0.86)  LDD1588  [4]
 LDCM0388  CL118 HEK-293T C289(0.98)  LDD1592  [4]
 LDCM0393  CL122 HEK-293T C289(1.17)  LDD1597  [4]
 LDCM0397  CL126 HEK-293T C289(0.92)  LDD1601  [4]
 LDCM0401  CL14 HEK-293T C289(1.32)  LDD1605  [4]
 LDCM0405  CL18 HEK-293T C289(0.69)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C289(1.51)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C289(1.21)  LDD1612  [4]
 LDCM0414  CL26 HEK-293T C289(1.36)  LDD1618  [4]
 LDCM0419  CL30 HEK-293T C289(1.18)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C289(1.27)  LDD1625  [4]
 LDCM0432  CL42 HEK-293T C289(0.76)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C289(1.18)  LDD1638  [4]
 LDCM0441  CL50 HEK-293T C289(1.05)  LDD1645  [4]
 LDCM0445  CL54 HEK-293T C289(0.60)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C289(1.22)  LDD1650  [4]
 LDCM0451  CL6 HEK-293T C289(0.71)  LDD1654  [4]
 LDCM0454  CL62 HEK-293T C289(0.84)  LDD1657  [4]
 LDCM0458  CL66 HEK-293T C289(0.64)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C289(1.35)  LDD1663  [4]
 LDCM0467  CL74 HEK-293T C289(0.96)  LDD1670  [4]
 LDCM0471  CL78 HEK-293T C289(0.76)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C289(0.84)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C289(1.07)  LDD1677  [4]
 LDCM0480  CL86 HEK-293T C289(0.93)  LDD1683  [4]
 LDCM0485  CL90 HEK-293T C289(0.87)  LDD1688  [4]
 LDCM0487  CL92 HEK-293T C289(1.43)  LDD1690  [4]
 LDCM0493  CL98 HEK-293T C289(0.86)  LDD1696  [4]
 LDCM0427  Fragment51 HEK-293T C289(1.46)  LDD1631  [4]
 LDCM0022  KB02 697 C307(1.19)  LDD2245  [1]
 LDCM0023  KB03 A101D C307(0.96)  LDD2667  [1]
 LDCM0024  KB05 IGR37 C307(1.39)  LDD3314  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 343 (ZNF343) Krueppel C2H2-type zinc-finger protein family Q6P1L6
POU domain, class 6, transcription factor 2 (POU6F2) POU transcription factor family P78424
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Brain-enriched guanylate kinase-associated protein (BEGAIN) . Q9BUH8
Brorin (VWC2) . Q2TAL6
Puratrophin-1 (PLEKHG4) . Q58EX7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402