Details of the Target

General Information of Target

Target ID LDTP13033
Target Name ABI gene family member 3 (ABI3)
Gene Name ABI3
Gene ID 51225
Synonyms
NESH; ABI gene family member 3; New molecule including SH3; Nesh
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVA
GKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYA
SVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHF
PARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVV
GFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLR
RSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV
Target Bioclass
Other
Family
ABI family
Subcellular location
Cytoplasm
Function May inhibit tumor metastasis. In vitro, reduces cell motility.
Uniprot ID
Q9P2A4
Ensemble ID
ENST00000225941.6
HGNC ID
HGNC:29859

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO27 SNV: p.G66D .
KARPAS422 SNV: p.T54P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C145(2.37)  LDD3339  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C137(1.17); C145(0.72)  LDD2187  [4]
 LDCM0572  Fragment10 Ramos C137(0.86)  LDD2189  [4]
 LDCM0573  Fragment11 Ramos C137(0.52); C145(0.03)  LDD2190  [4]
 LDCM0574  Fragment12 Ramos C137(1.24)  LDD2191  [4]
 LDCM0575  Fragment13 Ramos C137(0.96)  LDD2192  [4]
 LDCM0576  Fragment14 Ramos C137(0.64); C145(0.69)  LDD2193  [4]
 LDCM0579  Fragment20 Ramos C137(0.64)  LDD2194  [4]
 LDCM0580  Fragment21 Ramos C137(0.97)  LDD2195  [4]
 LDCM0582  Fragment23 Ramos C137(1.11)  LDD2196  [4]
 LDCM0578  Fragment27 Ramos C137(0.94)  LDD2197  [4]
 LDCM0586  Fragment28 Ramos C137(0.61); C145(0.77)  LDD2198  [4]
 LDCM0588  Fragment30 Ramos C137(1.12)  LDD2199  [4]
 LDCM0589  Fragment31 Ramos C137(0.97)  LDD2200  [4]
 LDCM0590  Fragment32 Ramos C137(1.09)  LDD2201  [4]
 LDCM0468  Fragment33 Ramos C137(0.99)  LDD2202  [4]
 LDCM0596  Fragment38 Ramos C137(0.83)  LDD2203  [4]
 LDCM0566  Fragment4 Ramos C137(0.71); C145(0.50)  LDD2184  [4]
 LDCM0610  Fragment52 Ramos C137(1.13)  LDD2204  [4]
 LDCM0614  Fragment56 Ramos C137(1.09)  LDD2205  [4]
 LDCM0569  Fragment7 Ramos C137(0.38); C145(0.62)  LDD2186  [4]
 LDCM0571  Fragment9 Ramos C137(0.71)  LDD2188  [4]
 LDCM0022  KB02 Ramos C137(0.33); C145(0.68)  LDD2182  [4]
 LDCM0023  KB03 Jurkat C137(4.71)  LDD0315  [3]
 LDCM0024  KB05 NALM-6 C145(2.37)  LDD3339  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Valine--tRNA ligase, mitochondrial (VARS2) Class-I aminoacyl-tRNA synthetase family Q5ST30
Phenylalanine--tRNA ligase alpha subunit (FARSA) Class-II aminoacyl-tRNA synthetase family Q9Y285
Desumoylating isopeptidase 1 (DESI1) DeSI family Q6ICB0
Dystrobrevin beta (DTNB) Dystrophin family O60941
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Syntaxin-1A (STX1A) Syntaxin family Q16623
Other
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
Centromere protein Q (CENPQ) CENP-Q/OKP1 family Q7L2Z9
Eukaryotic translation initiation factor 3 subunit H (EIF3H) EIF-3 subunit H family O15372
Eukaryotic translation initiation factor 3 subunit M (EIF3M) EIF-3 subunit M family Q7L2H7
Ena/VASP-like protein (EVL) Ena/VASP family Q9UI08
Vasodilator-stimulated phosphoprotein (VASP) Ena/VASP family P50552
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 (GNG13) G protein gamma family Q9P2W3
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Homer protein homolog 1 (HOMER1) Homer family Q86YM7
Homer protein homolog 3 (HOMER3) Homer family Q9NSC5
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 14 (KRT14) Intermediate filament family P02533
Keratin, type I cytoskeletal 24 (KRT24) Intermediate filament family Q2M2I5
Keratin, type I cytoskeletal 28 (KRT28) Intermediate filament family Q7Z3Y7
Phakinin (BFSP2) Intermediate filament family Q13515
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Kinesin light chain 4 (KLC4) Kinesin light chain family Q9NSK0
Mediator of RNA polymerase II transcription subunit 29 (MED29) Mediator complex subunit 29 family Q9NX70
Protein Mis18-alpha (MIS18A) Mis18 family Q9NYP9
Protein Mis18-beta (OIP5) Mis18 family O43482
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
NHS-like protein 2 (NHSL2) NHS family Q5HYW2
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Actin-binding protein WASF1 (WASF1) SCAR/WAVE family Q92558
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
Actin nucleation-promoting factor WAS (WAS) . P42768
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Cytoplasmic protein NCK2 (NCK2) . O43639
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Melanoma-associated antigen 12 (MAGEA12) . P43365
Protein RUFY3 (RUFY3) . Q7L099
Rho GTPase-activating protein 9 (ARHGAP9) . Q9BRR9
SH3 domain-binding protein 1 (SH3BP1) . Q9Y3L3
Uncharacterized protein KIAA0408 (KIAA0408) . Q6ZU52

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578