Details of the Target

General Information of Target

Target ID LDTP13028
Target Name Semaphorin-5B (SEMA5B)
Gene Name SEMA5B
Gene ID 54437
Synonyms
KIAA1445; SEMAG; Semaphorin-5B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPTLLQKLFNKRGSSGSSAAASAQGRAPKEGPAFSWSCSEFDLNEIRLIVYQDCDRRGR
QVLFDSKAVQKIEEVTAQKTEDVPIKISAKCCQGSSSVSSSSSSSISSHSSSGGSSHHAK
EQLPKYQYTRPASDVNMLGEMMFGSVAMSYKGSTLKIHYIRSPPQLMISKVFSARMGSFC
GSTNNLQDSFEYINQDPNLGKLNTNQNSLGPCRTGSNLAHSTPVDMPSRGQNEDRDSGIA
RSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQTTSLENGIIPRRSTDETFSLAEETCS
SNPAMVRRKKIAISIIFSLCEKEEAQRNFQDFFFSHFPLFESHMNRLKSAIEKAMISCRK
IAESSLRVQFYVSRLMEALGEFRGTIWNLYSVPRIAEPVWLTMMSGTLEKNQLCQRFLKE
FTLLIEQINKNQFFAALLTAVLTYHLAWVPTVMPVDHPPIKAFSEKRTSQSVNMLAKTHP
YNPLWAQLGDLYGAIGSPVRLTRTVVVGKQKDLVQRILYVLTYFLRCSELQENQLTWSGN
HGEGDQVLNGSKIITALEKGEVEESEYVVITVRNEPALVPPILPPTAAERHNPWPTGFPE
CPEGTDSRDLGLKPDKEANRRPEQGSEACSAGCLGPASDASWKPQNAFCGDEKNKEAPQD
GSSRLPSCEVLGAGMKMDQQAVCELLKVEMPTRLPDRSVAWPCPDRHLREKPSLEKVTFQ
IGSFASPESDFESRMKKMEERVKACGPSLEASEAADVAQDPQVSRSPFKPGFQENVCCPQ
NRLSEGDEGESDKGFAEDRGSRNDMAADIAGQLSHAADLGTASHGAGGTGGRRLEATRGL
YVKAAEGPVLEPVAPRCVQRGPGLVAGANIPCGDDNKKANFRTEGDIPRNESSDSALGDS
DDEACASAMLDLGHGGDRTGGSLEVELPLPRSQSISTQNVRNFGRSLLAGYCPTYMPDLV
LHGTGSDEKLKQCLVADLVHTVHHPVLDEPIAEAVCIIADTDKWSVQVATSQRKVTDNMK
LGQDVLVSSQVSSLLQSILQLYKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVH
VKELGVVLGIESNDLPLLTAIASTHSPYVAQILL
Target Bioclass
Other
Family
Semaphorin family
Subcellular location
Membrane
Function May act as a positive axonal guidance cue.
Uniprot ID
Q9P283
Ensemble ID
ENST00000357599.8
HGNC ID
HGNC:10737

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.A695S .
HCC1395 SNV: p.I223M .
HUH28 SNV: p.S918L .
JURKAT SNV: p.S735N .
JURLMK1 SNV: p.T465P .
KYSE410 SNV: p.S530N .
L428 SNV: p.F798V .
LU65 SNV: p.A655S .
MCC13 SNV: p.E515K .
MCC26 SNV: p.P7S .
MDST8 SNV: p.K222N .
MEWO SNV: p.W667Ter; p.S863L .
MOLT4 SNV: p.R343W .
NCIH2286 SNV: p.C346R .
SNU5 SNV: p.W919C .
WM2664 SNV: p.R637Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C364(2.13); C745(2.24)  LDD3434  [1]
AHL-Pu-1
 Probe Info  		C208(3.72)  LDD0168  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C208(3.72)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C208(10.10)  LDD0169  [2]
 LDCM0022  KB02 786-O C364(1.58)  LDD2247  [1]
 LDCM0023  KB03 786-O C364(1.54)  LDD2664  [1]
 LDCM0024  KB05 SK-N-MC C364(2.13); C745(2.24)  LDD3434  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625