Details of the Target

General Information of Target

Target ID LDTP13009
Target Name Whirlin (WHRN)
Gene Name WHRN
Gene ID 25861
Synonyms
DFNB31; KIAA1526; Whirlin; Autosomal recessive deafness type 31 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKF
SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE
ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISS
IPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM
TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH
ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY
QEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR
GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGA
RDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA
MDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKP
VLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPV
RAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLP
QRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Involved in hearing and vision as member of the USH2 complex. Necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear. Involved in the maintenance of the hair bundle ankle region, which connects stereocilia in cochlear hair cells of the inner ear. In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.
Uniprot ID
Q9P202
Ensemble ID
ENST00000265134.10
HGNC ID
HGNC:16361

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 Deletion: p.D286TfsTer42 .
AN3CA SNV: p.K465E .
CHL1 SNV: p.G575E .
HCC44 SNV: p.S527L .
ICC10 SNV: p.Q103R .
ICC106 SNV: p.Q103R .
ICC108 SNV: p.Q103R .
JHH7 SNV: p.V905M .
KNS42 SNV: p.R55Q .
MOLT4 SNV: p.R144W .
NCIH1703 SNV: p.A471D .
NCIH2286 SNV: p.V218L .
RKO SNV: p.T355A .
SISO SNV: p.P408L .
SSP25 SNV: p.N868S .
SUPT1 Insertion: p.G274RfsTer4 .
YSCCC SNV: p.S648F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C855(0.88)  LDD3493  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C855(0.93)  LDD1513  [2]
 LDCM0283  AC23 HEK-293T C855(1.11)  LDD1522  [2]
 LDCM0292  AC31 HEK-293T C855(1.00)  LDD1531  [2]
 LDCM0300  AC39 HEK-293T C855(0.88)  LDD1539  [2]
 LDCM0309  AC47 HEK-293T C855(1.12)  LDD1548  [2]
 LDCM0318  AC55 HEK-293T C855(1.19)  LDD1557  [2]
 LDCM0327  AC63 HEK-293T C855(1.15)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C855(1.25)  LDD1568  [2]
 LDCM0379  CL11 HEK-293T C855(1.07)  LDD1583  [2]
 LDCM0411  CL23 HEK-293T C855(1.06)  LDD1615  [2]
 LDCM0424  CL35 HEK-293T C855(1.07)  LDD1628  [2]
 LDCM0437  CL47 HEK-293T C855(1.29)  LDD1641  [2]
 LDCM0450  CL59 HEK-293T C855(0.87)  LDD1653  [2]
 LDCM0464  CL71 HEK-293T C855(0.91)  LDD1667  [2]
 LDCM0477  CL83 HEK-293T C855(0.94)  LDD1680  [2]
 LDCM0490  CL95 HEK-293T C855(1.35)  LDD1693  [2]
 LDCM0022  KB02 CAL-148 C855(2.01)  LDD2285  [1]
 LDCM0023  KB03 CAL-148 C855(2.17)  LDD2702  [1]
 LDCM0024  KB05 ZR-75-1 C855(0.88)  LDD3493  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402