Details of the Target
General Information of Target
| Target ID | LDTP12733 | |||||
|---|---|---|---|---|---|---|
| Target Name | Small ribosomal subunit protein mS38 (AURKAIP1) | |||||
| Gene Name | AURKAIP1 | |||||
| Gene ID | 54998 | |||||
| Synonyms |
AIP; AKIP; MRPS38; Small ribosomal subunit protein mS38; 28S ribosomal protein S38, mitochondrial; MRP-S38; Aurora kinase A-interacting protein; AURKA-interacting protein |
|||||
| 3D Structure | ||||||
| Sequence |
MAATAAEAVASGSGEPREEAGALGPAWDESQLRSYSFPTRPIPRLSQSDPRAEELIENEE
PVVLTDTNLVYPALKWDLEYLQENIGNGDFSVYSASTHKFLYYDEKKMANFQNFKPRSNR EEMKFHEFVEKLQDIQQRGGEERLYLQQTLNDTVGRKIVMDFLGFNWNWINKQQGKRGWG QLTSNLLLIGMEGNVTPAHYDEQQNFFAQIKGYKRCILFPPDQFECLYPYPVHHPCDRQS QVDFDNPDYERFPNFQNVVGYETVVGPGDVLYIPMYWWHHIESLLNGGITITVNFWYKGA PTPKRIEYPLKAHQKVAIMRNIEKMLGEALGNPQEVGPLLNTMIKGRYN |
|||||
| Target Bioclass |
Other
|
|||||
| Family |
Mitochondrion-specific ribosomal protein mS38 family
|
|||||
| Subcellular location |
Mitochondrion
|
|||||
| Function | May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
C-Sul Probe Info |
 |
4.59 | LDD0066 | [1] | |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| (Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4) | Peptidase S33 family | Q8TB40 | |||
| Aurora kinase A (AURKA) | Ser/Thr protein kinase family | O14965 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Beta-defensin 127 (DEFB127) | Beta-defensin family | Q9H1M4 | |||
| Protein FAM9B (FAM9B) | FAM9 family | Q8IZU0 | |||