Details of the Target

General Information of Target

Target ID LDTP12491
Target Name Platelet-derived growth factor C (PDGFC)
Gene Name PDGFC
Gene ID 56034
Synonyms
SCDGF; Platelet-derived growth factor C; PDGF-C; Fallotein; Spinal cord-derived growth factor; SCDGF; VEGF-E) [Cleaved into: Platelet-derived growth factor C, latent form; PDGFC latent form; Platelet-derived growth factor C, receptor-binding form; PDGFC receptor-binding form)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
Target Type
Literature-reported
Target Bioclass
Other
Family
PDGF/VEGF growth factor family
Subcellular location
Cytoplasm, cytosol
Function
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function.
TTD ID
T59510
Uniprot ID
Q9NRA1
DrugMap ID
TTOABM9
Ensemble ID
ENST00000422544.2
HGNC ID
HGNC:8801

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G282V .
Ishikawa (Heraklio) 02 ER Deletion: p.P178LfsTer13 .
MCC26 SNV: p.S299N .
MDAMB436 Deletion: p.F4SfsTer6 .
MFE319 SNV: p.G281V .
NCIH1793 SNV: p.Q133H .
TE4 SNV: p.V277F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C274(0.97)  LDD1573  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C274(0.97)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C274(1.01)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C274(0.92)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C274(1.12)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C274(1.09)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C274(1.02)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C274(1.12)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C274(1.08)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C274(1.02)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C274(0.94)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C274(0.99)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C274(0.94)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C274(1.00)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C274(1.06)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C274(1.02)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C274(0.98)  LDD1685  [1]
 LDCM0022  KB02 A204 C124(2.50)  LDD2252  [2]
 LDCM0023  KB03 A204 C124(3.49)  LDD2669  [2]
 LDCM0024  KB05 A204 C124(3.76)  LDD3086  [2]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840