Details of the Target

General Information of Target

Target ID LDTP12416
Target Name Protein MANBAL (MANBAL)
Gene Name MANBAL
Gene ID 63905
Synonyms
Protein MANBAL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEEQVNRSAGLAPDCEASATAETTVSSVGTCEAAGKSPEPKDYDSTCVFCRIAGRQDPG
TELLHCENEDLICFKDIKPAATHHYLVVPKKHIGNCRTLRKDQVELVENMVTVGKTILER
NNFTDFTNVRMGFHMPPFCSISHLHLHVLAPVDQLGFLSKLVYRVNSYWFITADHLIEKL
RT
Target Bioclass
Other
Family
UPF0239 family
Subcellular location
Membrane
Uniprot ID
Q9NQG1
Ensemble ID
ENST00000373605.7
HGNC ID
HGNC:15799

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		3.06  LDD0066  [1]
Acrolein
 Probe Info  		N.A.  LDD0217  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kallikrein-5 (KLK5) Peptidase S1 family Q9Y337
Phosphatidylinositol-glycan biosynthesis class F protein (PIGF) PIGF family Q07326
Vitamin K epoxide reductase complex subunit 1 (VKORC1) VKOR family Q9BQB6
E3 ubiquitin-protein ligase MARCHF5 (MARCHF5) . Q9NX47
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bax inhibitor 1 (TMBIM6) BI1 family P55061
NIPA-like protein 3 (NIPAL3) NIPA family Q6P499
Proton channel OTOP2 (OTOP2) Otopetrin family Q7RTS6
Syntaxin-3 (STX3) Syntaxin family Q13277
Vesicle transport through interaction with t-SNAREs homolog 1B (VTI1B) VTI1 family Q9UEU0
Zinc transporter ZIP9 (SLC39A9) ZIP transporter (TC 2.A.5) family Q9NUM3
Transmembrane protein 203 (TMEM203) . Q969S6
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 2 (CMTM2) Chemokine-like factor family Q8TAZ6
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MAL-like protein (MALL) MAL family Q13021
Mannose-P-dolichol utilization defect 1 protein (MPDU1) MPDU1 (TC 2.A.43.3) family O75352
Scrapie-responsive protein 1 (SCRG1) SCRG1 family O75711
Transmembrane protein 115 (TMEM115) TMEM115 family Q12893
Cation channel sperm-associated auxiliary subunit TMEM262 (TMEM262) . E9PQX1

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.