Details of the Target
General Information of Target
| Target ID | LDTP12243 | |||||
|---|---|---|---|---|---|---|
| Target Name | Synaptotagmin-like protein 2 (SYTL2) | |||||
| Gene Name | SYTL2 | |||||
| Gene ID | 54843 | |||||
| Synonyms |
KIAA1597; SGA72M; SLP2; SLP2A; Synaptotagmin-like protein 2; Breast cancer-associated antigen SGA-72M; Exophilin-4 |
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| 3D Structure | ||||||
| Sequence |
MEQPEDMASLSEFDSLAGSIPATKVEITVSCRNLLDKDMFSKSDPLCVMYTQGMENKQWR
EFGRTEVIDNTLNPDFVRKFIVDYFFEEKQNLRFDLYDVDSKSPDLSKHDFLGQAFCTLG EIVGSPGSRLEKPLTIGAFSLNSRTGKPMPAVSNGGVPGKKCGTIILSAEELSNCRDVAT MQFCANKLDKKDFFGKSDPFLVFYRSNEDGTFTICHKTEVMKNTLNPVWQTFSIPVRALC NGDYDRTIKVEVYDWDRDGSHDFIGEFTTSYRELARGQSQFNIYEVVNPKKKMKKKKYVN SGTVTLLSFAVESECTFLDYIKGGTQINFTVAIDFTASNGNPSQSTSLHYMSPYQLNAYA LALTAVGEIIQHYDSDKMFPALGFGAKLPPDGRVSHEFPLNGNQENPSCCGIDGILEAYH RSLRTVQLYGPTNFAPVVTHVARNAAAVQDGSQYSVLLIITDGVISDMAQTKEAIVNAAK LPMSIIIVGVGQAEFDAMVELDGDDVRISSRGKLAERDIVQFVPFRDYVDRTGNHVLSMA RLARDVLAEIPDQLVSYMKAQGIRPRPPPAAPTHSPSQSPARTPPASPLHTHI |
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| Target Bioclass |
Transporter and channel
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| Subcellular location |
Cytoplasm; Cell membrane
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| Function |
Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
Probe 1 Probe Info |
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Y672(16.25) | LDD3495 | [1] | |
|
DBIA Probe Info |
 |
C802(7.16); C469(1.75) | LDD3314 | [2] | |
|
AHL-Pu-1 Probe Info |
 |
C468(2.42) | LDD0170 | [3] | |
|
HHS-475 Probe Info |
 |
Y672(0.40); Y289(7.73) | LDD0264 | [4] | |
|
NAIA_5 Probe Info |
 |
N.A. | LDD2223 | [5] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0025 | 4SU-RNA | DM93 | C468(2.42) | LDD0170 | [3] |
| LDCM0026 | 4SU-RNA+native RNA | DM93 | C468(3.39) | LDD0171 | [3] |
| LDCM0632 | CL-Sc | Hep-G2 | C801(0.68) | LDD2227 | [5] |
| LDCM0116 | HHS-0101 | DM93 | Y672(0.40); Y289(7.73) | LDD0264 | [4] |
| LDCM0117 | HHS-0201 | DM93 | Y672(0.47); Y289(7.12) | LDD0265 | [4] |
| LDCM0118 | HHS-0301 | DM93 | Y672(0.16); Y289(5.34) | LDD0266 | [4] |
| LDCM0119 | HHS-0401 | DM93 | Y672(0.39); Y289(10.32) | LDD0267 | [4] |
| LDCM0120 | HHS-0701 | DM93 | Y672(0.35); Y289(8.00) | LDD0268 | [4] |
| LDCM0022 | KB02 | 42-MG-BA | C469(1.14) | LDD2244 | [2] |
| LDCM0023 | KB03 | A2058 | C802(1.74); C990(2.13) | LDD2670 | [2] |
| LDCM0024 | KB05 | IGR37 | C802(7.16); C469(1.75) | LDD3314 | [2] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) | PPP phosphatase family | P62136 | |||
| E3 ubiquitin-protein ligase LNX (LNX1) | . | Q8TBB1 | |||
Other
| Protein name | Family | Uniprot ID | |||
|---|---|---|---|---|---|
| Protein YIF1A (YIF1A) | YIF1 family | O95070 | |||
| MORN repeat-containing protein 4 (MORN4) | . | Q8NDC4 | |||
References