Details of the Target

General Information of Target

Target ID LDTP12226
Target Name Spondin-1 (SPON1)
Gene Name SPON1
Gene ID 10418
Synonyms
KIAA0762; VSGP; Spondin-1; F-spondin; Vascular smooth muscle cell growth-promoting factor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGQPGHMPHGGSSNNLCHTLGPVHPPDPQRHPNTLSFRCSLADFQIEKKIGRGQFSEVY
KATCLLDRKTVALKKVQIFEMMDAKARQDCVKEIGLLKQLNHPNIIKYLDSFIEDNELNI
VLELADAGDLSQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFI
TATGVVKLGDLGLGRFFSSETTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEM
AALQSPFYGDKMNLFSLCQKIEQCDYPPLPGEHYSEKLRELVSMCICPDPHQRPDIGYVH
QVAKQMHIWMSST
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS. Major factor for vascular smooth muscle cell.
Uniprot ID
Q9HCB6
Ensemble ID
ENST00000576479.4
HGNC ID
HGNC:11252

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C340(3.77); C770(3.43); C595(2.12); C44(3.55)  LDD3365  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0164  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C340(1.07)  LDD1509  [5]
 LDCM0270  AC15 HEK-293T C793(0.99)  LDD1513  [5]
 LDCM0278  AC19 HEK-293T C340(1.19)  LDD1517  [5]
 LDCM0283  AC23 HEK-293T C793(0.90)  LDD1522  [5]
 LDCM0287  AC27 HEK-293T C340(1.01)  LDD1526  [5]
 LDCM0290  AC3 HEK-293T C340(1.06)  LDD1529  [5]
 LDCM0292  AC31 HEK-293T C793(0.97)  LDD1531  [5]
 LDCM0296  AC35 HEK-293T C340(1.10)  LDD1535  [5]
 LDCM0300  AC39 HEK-293T C793(1.03)  LDD1539  [5]
 LDCM0305  AC43 HEK-293T C340(1.11)  LDD1544  [5]
 LDCM0309  AC47 HEK-293T C793(1.05)  LDD1548  [5]
 LDCM0314  AC51 HEK-293T C340(1.02)  LDD1553  [5]
 LDCM0318  AC55 HEK-293T C793(0.96)  LDD1557  [5]
 LDCM0322  AC59 HEK-293T C340(1.04)  LDD1561  [5]
 LDCM0327  AC63 HEK-293T C793(0.92)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C793(1.02)  LDD1568  [5]
 LDCM0379  CL11 HEK-293T C793(0.94)  LDD1583  [5]
 LDCM0406  CL19 HEK-293T C340(1.09)  LDD1610  [5]
 LDCM0411  CL23 HEK-293T C793(0.99)  LDD1615  [5]
 LDCM0420  CL31 HEK-293T C340(1.09)  LDD1624  [5]
 LDCM0424  CL35 HEK-293T C793(0.88)  LDD1628  [5]
 LDCM0433  CL43 HEK-293T C340(1.03)  LDD1637  [5]
 LDCM0437  CL47 HEK-293T C793(1.08)  LDD1641  [5]
 LDCM0446  CL55 HEK-293T C340(1.12)  LDD1649  [5]
 LDCM0450  CL59 HEK-293T C793(0.96)  LDD1653  [5]
 LDCM0459  CL67 HEK-293T C340(1.17)  LDD1662  [5]
 LDCM0462  CL7 HEK-293T C340(1.13)  LDD1665  [5]
 LDCM0464  CL71 HEK-293T C793(0.95)  LDD1667  [5]
 LDCM0472  CL79 HEK-293T C340(1.03)  LDD1675  [5]
 LDCM0477  CL83 HEK-293T C793(0.99)  LDD1680  [5]
 LDCM0486  CL91 HEK-293T C340(1.03)  LDD1689  [5]
 LDCM0490  CL95 HEK-293T C793(1.04)  LDD1693  [5]
 LDCM0022  KB02 A2780 C770(1.60); C44(1.11)  LDD2254  [2]
 LDCM0023  KB03 A2780 C770(1.67)  LDD2671  [2]
 LDCM0024  KB05 OVCAR-3 C340(3.77); C770(3.43); C595(2.12); C44(3.55)  LDD3365  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402