Details of the Target
General Information of Target
| Target ID | LDTP12176 | |||||
|---|---|---|---|---|---|---|
| Target Name | Intraflagellar transport protein 122 homolog (IFT122) | |||||
| Gene Name | IFT122 | |||||
| Gene ID | 55764 | |||||
| Synonyms |
SPG; WDR10; WDR140; Intraflagellar transport protein 122 homolog; WD repeat-containing protein 10; WD repeat-containing protein 140 |
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| 3D Structure | ||||||
| Sequence |
MVSVFRSEEMCLSQLFLQVEAAYCCVAELGELGLVQFKDLNMNVNSFQRKFVNEVRRCES
LERILRFLEDEMQNEIVVQLLEKSPLTPLPREMITLETVLEKLEGELQEANQNQQALKQS FLELTELKYLLKKTQDFFETETNLADDFFTEDTSGLLELKAVPAYMTGKLGFIAGVINRE RMASFERLLWRICRGNVYLKFSEMDAPLEDPVTKEEIQKNIFIIFYQGEQLRQKIKKICD GFRATVYPCPEPAVERREMLESVNVRLEDLITVITQTESHRQRLLQEAAANWHSWLIKVQ KMKAVYHILNMCNIDVTQQCVIAEIWFPVADATRIKRALEQGMELSGSSMAPIMTTVQSK TAPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGTVMLL AALWMILNERRLLSQKTDNEIWNTFFHGRYLILLMGIFSIYTGLIYNDCFSKSLNIFGSS WSVQPMFRNGTWNTHVMEESLYLQLDPAIPGVYFGNPYPFGIDPIWNLASNKLTFLNSYK MKMSVILGIVQMVFGVILSLFNHIYFRRTLNIILQFIPEMIFILCLFGYLVFMIIFKWCC FDVHVSQHAPSILIHFINMFLFNYSDSSNAPLYKHQQEVQSFFVVMALISVPWMLLIKPF ILRASHRKSQLQASRIQEDATENIEGDSSSPSSRSGQRTSADTHGALDDHGEEFNFGDVF VHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVMNSGLQTRGWGGIVGVFI IFAVFAVLTVAILLIMEGLSAFLHALRLHWVEFQNKFYVGDGYKFSPFSFKHILDGTAEE |
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| Target Bioclass |
Transporter and channel
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| Subcellular location |
Cell projection, cilium
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| Function |
As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is required in ciliogenesis and ciliary protein trafficking. Involved in cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C519(9.68) | LDD0204 | [1] | |
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IA-alkyne Probe Info |
 |
N.A. | LDD0165 | [2] | |
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IPM Probe Info |
 |
N.A. | LDD2156 | [3] | |
|
AOyne Probe Info |
 |
15.00 | LDD0443 | [4] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0102 | BDHI 8 | Jurkat | C519(9.68) | LDD0204 | [1] |
| LDCM0630 | CCW28-3 | 231MFP | C1060(0.01); C1077(0.01) | LDD2214 | [5] |
| LDCM0022 | KB02 | A101D | C570(1.64) | LDD2250 | [6] |
| LDCM0023 | KB03 | Jurkat | C811(58.71); C456(91.80) | LDD0209 | [1] |
| LDCM0024 | KB05 | MKN-1 | C570(2.24) | LDD3331 | [6] |
The Interaction Atlas With This Target
References