Details of the Target

General Information of Target

Target ID LDTP12028
Target Name Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3)
Gene Name SUDS3
Gene ID 64426
Synonyms
SAP45; SDS3; Sin3 histone deacetylase corepressor complex component SDS3; 45 kDa Sin3-associated polypeptide; Suppressor of defective silencing 3 protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAALKCLLTLGRWCPGLGVAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPH
VRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLEN
PDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRAR
NPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEP
YIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTK
AGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSW
NKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRH
GRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES
Target Bioclass
Other
Family
SDS3 family
Subcellular location
Nucleus
Function
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Uniprot ID
Q9H7L9
Ensemble ID
ENST00000543473.2
HGNC ID
HGNC:29545

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y95(12.07); Y106(132.46)  LDD3495  [1]
m-APA
 Probe Info  		15.00  LDD0403  [2]
DBIA
 Probe Info  		C287(1.93)  LDD3352  [3]
CY4
 Probe Info  		D281(0.00); Q283(0.00)  LDD0247  [4]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [2]
 LDCM0022  KB02 CDX: HA1; Afatinib resistant C287(1.34)  LDD2346  [3]
 LDCM0023  KB03 CDX: HA1; Afatinib resistant C287(1.35)  LDD2763  [3]
 LDCM0024  KB05 NCI-H1975 C287(1.93)  LDD3352  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer metastasis-suppressor 1 (BRMS1) BRMS1 family Q9HCU9
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein LDOC1 (LDOC1) LDOC1 family O95751
Host cell factor 1 (HCFC1) . P51610

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.