Details of the Target

General Information of Target

Target ID LDTP11933
Target Name Pleckstrin homology domain-containing family A member 4 (PLEKHA4)
Gene Name PLEKHA4
Gene ID 57664
Synonyms
PEPP1; Pleckstrin homology domain-containing family A member 4; PH domain-containing family A member 4; Phosphoinositol 3-phosphate-binding protein 1; PEPP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITED
WDQPVADWKIFYFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLSRDQRKEFPND
QVKKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEVKDWFAARPDCGSKYQLCVQL
LSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIWFQHGGVDTHYWAGWYG
PRVTNSSITIGPPLP
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides.
Uniprot ID
Q9H4M7
Ensemble ID
ENST00000263265.11
HGNC ID
HGNC:14339

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.P511L .
HCT15 SNV: p.W748Ter .
KMRC1 SNV: p.A267S .
MCC26 SNV: p.P574S .
MFE319 SNV: p.S94I .
RKO SNV: p.L354P .
RL952 SNV: p.S711L .
SF295 SNV: p.Q394R .
SKMEL3 Deletion: p.T622HfsTer17 .
SUPT1 SNV: p.P576L .
TGBC1TKB SNV: p.S473C .
TOV21G SNV: p.G755W .
UMUC3 Deletion: p.M691del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C438(1.54)  LDD3383  [1]
AHL-Pu-1
 Probe Info  		C438(3.49)  LDD0171  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C438(3.49)  LDD0171  [2]
 LDCM0022  KB02 A2058 C438(1.93)  LDD2253  [1]
 LDCM0023  KB03 A2058 C438(1.72)  LDD2670  [1]
 LDCM0024  KB05 OVCAR-5 C438(1.54)  LDD3383  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Meiosis-specific protein MEI4 (MEI4) MEI4L family A8MW99
Kelch-like protein 12 (KLHL12) . Q53G59

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Inositol 1345-tetrakisphosphate Small molecular drug DB01863

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625