Details of the Target

General Information of Target

Target ID LDTP11884
Target Name Semaphorin-4A (SEMA4A)
Gene Name SEMA4A
Gene ID 64218
Synonyms
SEMAB; SEMB; Semaphorin-4A; Semaphorin-B; Sema B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSM
VDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKIS
RQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKN
KQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQL
EKNVDMM
Target Bioclass
Other
Family
Semaphorin family
Subcellular location
Cell membrane
Function
Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
Uniprot ID
Q9H3S1
Ensemble ID
ENST00000355014.6
HGNC ID
HGNC:10729

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A289V .
AU565 SNV: p.G441E .
CAL51 SNV: p.C624Ter .
CCK81 SNV: p.F115L; p.A728V .
HCT15 SNV: p.K715N .
JURKAT SNV: p.C142Y; p.G488S .
NCIH2286 SNV: p.L674M .
NCIH446 SNV: p.G143C .
OVK18 SNV: p.V402L .
SNU1196 SNV: p.R561C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C719(2.12); C755(1.38)  LDD0304  [1]
DBIA
 Probe Info  		C379(2.72)  LDD3333  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C719(0.93)  LDD2187  [3]
 LDCM0572  Fragment10 Ramos C719(2.91)  LDD2189  [3]
 LDCM0573  Fragment11 Ramos C719(0.98)  LDD2190  [3]
 LDCM0574  Fragment12 Ramos C719(1.48)  LDD2191  [3]
 LDCM0575  Fragment13 Ramos C719(0.89)  LDD2192  [3]
 LDCM0576  Fragment14 Ramos C719(1.55)  LDD2193  [3]
 LDCM0579  Fragment20 Ramos C719(2.76)  LDD2194  [3]
 LDCM0580  Fragment21 Ramos C719(0.88)  LDD2195  [3]
 LDCM0582  Fragment23 Ramos C719(1.08)  LDD2196  [3]
 LDCM0578  Fragment27 Ramos C719(0.86)  LDD2197  [3]
 LDCM0586  Fragment28 Ramos C719(0.76)  LDD2198  [3]
 LDCM0588  Fragment30 Ramos C719(1.29)  LDD2199  [3]
 LDCM0589  Fragment31 Ramos C719(0.87)  LDD2200  [3]
 LDCM0590  Fragment32 Ramos C719(1.95)  LDD2201  [3]
 LDCM0468  Fragment33 Ramos C719(1.10)  LDD2202  [3]
 LDCM0596  Fragment38 Ramos C719(1.39)  LDD2203  [3]
 LDCM0566  Fragment4 Ramos C719(1.31)  LDD2184  [3]
 LDCM0610  Fragment52 Ramos C719(1.04)  LDD2204  [3]
 LDCM0614  Fragment56 Ramos C719(1.15)  LDD2205  [3]
 LDCM0569  Fragment7 Ramos C719(1.50)  LDD2186  [3]
 LDCM0571  Fragment9 Ramos C719(3.07)  LDD2188  [3]
 LDCM0022  KB02 Ramos C719(2.19)  LDD2182  [3]
 LDCM0023  KB03 Ramos C719(1.37)  LDD2183  [3]
 LDCM0024  KB05 MOLM-13 C379(2.72)  LDD3333  [2]
 LDCM0131  RA190 MM1.R C719(2.12); C755(1.38)  LDD0304  [1]

References

1 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578