Details of the Target

General Information of Target

Target ID LDTP11853
Target Name Cell death-inducing p53-target protein 1 (CDIP1)
Gene Name CDIP1
Gene ID 29965
Synonyms
C16orf5; CDIP; LITAFL; Cell death-inducing p53-target protein 1; Cell death involved p53-target; Cell death-inducing protein; LITAF-like protein; Lipopolysaccharide-induced tumor necrosis factor-alpha-like protein; Transmembrane protein I1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAWRGWAQRGWGCGQAWGASVGGRSCEELTAVLTPPQLLGRRFNFFIQQKCGFRKAPRKV
EPRRSDPGTSGEAYKRSALIPPVEETVFYPSPYPIRSLIKPLFFTVGFTGCAFGSAAIWQ
YESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEINKWWNNLSDGQRTVTGIIAANVLVF
CLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNIL
GQEQFMAVYLSAGVISNFVSYVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIF
LPMFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYVTYGHELIWKNREPL
VKIWHEIRTNGPKKGGGSK
Target Bioclass
Other
Family
CDIP1/LITAF family
Subcellular location
Late endosome membrane
Function Acts as an important p53/TP53-apoptotic effector. Regulates TNF-alpha-mediated apoptosis in a p53/TP53-dependent manner.
Uniprot ID
Q9H305
Ensemble ID
ENST00000399599.7
HGNC ID
HGNC:13234

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P26S .
NCIH1993 Substitution: p.C142V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C197(1.05)  LDD1509  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C197(1.05)  LDD1509  [1]
 LDCM0259  AC14 HEK-293T C197(1.24)  LDD1512  [1]
 LDCM0278  AC19 HEK-293T C197(0.45)  LDD1517  [1]
 LDCM0282  AC22 HEK-293T C197(1.05)  LDD1521  [1]
 LDCM0287  AC27 HEK-293T C197(1.21)  LDD1526  [1]
 LDCM0290  AC3 HEK-293T C197(1.02)  LDD1529  [1]
 LDCM0291  AC30 HEK-293T C197(1.09)  LDD1530  [1]
 LDCM0296  AC35 HEK-293T C197(1.08)  LDD1535  [1]
 LDCM0299  AC38 HEK-293T C197(1.14)  LDD1538  [1]
 LDCM0305  AC43 HEK-293T C197(1.14)  LDD1544  [1]
 LDCM0308  AC46 HEK-293T C197(1.15)  LDD1547  [1]
 LDCM0314  AC51 HEK-293T C197(0.97)  LDD1553  [1]
 LDCM0317  AC54 HEK-293T C197(0.95)  LDD1556  [1]
 LDCM0322  AC59 HEK-293T C197(1.40)  LDD1561  [1]
 LDCM0323  AC6 HEK-293T C197(0.78)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C197(1.04)  LDD1565  [1]
 LDCM0368  CL10 HEK-293T C197(1.37)  LDD1572  [1]
 LDCM0406  CL19 HEK-293T C197(1.07)  LDD1610  [1]
 LDCM0410  CL22 HEK-293T C197(1.46)  LDD1614  [1]
 LDCM0420  CL31 HEK-293T C197(1.31)  LDD1624  [1]
 LDCM0423  CL34 HEK-293T C197(1.23)  LDD1627  [1]
 LDCM0433  CL43 HEK-293T C197(1.79)  LDD1637  [1]
 LDCM0436  CL46 HEK-293T C197(1.41)  LDD1640  [1]
 LDCM0446  CL55 HEK-293T C197(1.23)  LDD1649  [1]
 LDCM0449  CL58 HEK-293T C197(1.19)  LDD1652  [1]
 LDCM0459  CL67 HEK-293T C197(1.02)  LDD1662  [1]
 LDCM0462  CL7 HEK-293T C197(1.24)  LDD1665  [1]
 LDCM0463  CL70 HEK-293T C197(1.49)  LDD1666  [1]
 LDCM0472  CL79 HEK-293T C197(1.09)  LDD1675  [1]
 LDCM0476  CL82 HEK-293T C197(1.49)  LDD1679  [1]
 LDCM0486  CL91 HEK-293T C197(1.13)  LDD1689  [1]
 LDCM0489  CL94 HEK-293T C197(1.10)  LDD1692  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402