Details of the Target
General Information of Target
Target ID | LDTP11713 | |||||
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Target Name | Enkurin domain-containing protein 1 (ENKD1) | |||||
Gene Name | ENKD1 | |||||
Gene ID | 84080 | |||||
Synonyms |
C16orf48; Enkurin domain-containing protein 1 |
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3D Structure | ||||||
Sequence |
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMK
AETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEE QKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKR EKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVP YWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESC VPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSP MIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIHAICS LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL QRVAQSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLLSLPLEYWS QFMMVEQENIDPLHVIENSNAFSTPQTPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRS TLTKNTPRFGSKSKSATNLGRQGNFFASPMLK |
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Target Bioclass |
Other
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Subcellular location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Function |
Microtubule-binding protein which regulates microtubule organization and stability. Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle. This allows the oriented division of basal keratinocytes and contributes to epidermal stratification. Required for the assembly of both primary and motile cilia. Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis.
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Uniprot ID | ||||||
Ensemble ID | ||||||
HGNC ID |
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
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DBIA Probe Info |
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C58(0.84) | LDD1507 | [1] | |
IPM Probe Info |
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N.A. | LDD2156 | [2] |
Competitor(s) Related to This Target
Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
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LDCM0214 | AC1 | HEK-293T | C58(0.84) | LDD1507 | [1] |
LDCM0270 | AC15 | HEK-293T | C58(1.06) | LDD1513 | [1] |
LDCM0276 | AC17 | HEK-293T | C58(0.96) | LDD1515 | [1] |
LDCM0281 | AC21 | HEK-293T | C19(0.99) | LDD1520 | [1] |
LDCM0283 | AC23 | HEK-293T | C58(1.23) | LDD1522 | [1] |
LDCM0285 | AC25 | HEK-293T | C58(0.98) | LDD1524 | [1] |
LDCM0289 | AC29 | HEK-293T | C19(0.99) | LDD1528 | [1] |
LDCM0292 | AC31 | HEK-293T | C58(1.48) | LDD1531 | [1] |
LDCM0294 | AC33 | HEK-293T | C58(0.94) | LDD1533 | [1] |
LDCM0298 | AC37 | HEK-293T | C19(1.01) | LDD1537 | [1] |
LDCM0300 | AC39 | HEK-293T | C58(1.16) | LDD1539 | [1] |
LDCM0303 | AC41 | HEK-293T | C58(0.93) | LDD1542 | [1] |
LDCM0307 | AC45 | HEK-293T | C19(1.12) | LDD1546 | [1] |
LDCM0309 | AC47 | HEK-293T | C58(0.98) | LDD1548 | [1] |
LDCM0311 | AC49 | HEK-293T | C58(0.90) | LDD1550 | [1] |
LDCM0312 | AC5 | HEK-293T | C19(0.98) | LDD1551 | [1] |
LDCM0316 | AC53 | HEK-293T | C19(1.01) | LDD1555 | [1] |
LDCM0318 | AC55 | HEK-293T | C58(1.11) | LDD1557 | [1] |
LDCM0320 | AC57 | HEK-293T | C58(0.95) | LDD1559 | [1] |
LDCM0325 | AC61 | HEK-293T | C19(1.12) | LDD1564 | [1] |
LDCM0327 | AC63 | HEK-293T | C58(1.19) | LDD1566 | [1] |
LDCM0334 | AC7 | HEK-293T | C58(1.05) | LDD1568 | [1] |
LDCM0248 | AKOS034007472 | HEK-293T | C19(1.02) | LDD1511 | [1] |
LDCM0356 | AKOS034007680 | HEK-293T | C58(1.11) | LDD1570 | [1] |
LDCM0371 | CL102 | HEK-293T | C58(0.84) | LDD1575 | [1] |
LDCM0372 | CL103 | HEK-293T | C58(1.26) | LDD1576 | [1] |
LDCM0375 | CL106 | HEK-293T | C58(0.96) | LDD1579 | [1] |
LDCM0376 | CL107 | HEK-293T | C58(0.80) | LDD1580 | [1] |
LDCM0379 | CL11 | HEK-293T | C58(0.92) | LDD1583 | [1] |
LDCM0380 | CL110 | HEK-293T | C58(0.88) | LDD1584 | [1] |
LDCM0381 | CL111 | HEK-293T | C58(1.30) | LDD1585 | [1] |
LDCM0384 | CL114 | HEK-293T | C58(1.15) | LDD1588 | [1] |
LDCM0385 | CL115 | HEK-293T | C58(1.18) | LDD1589 | [1] |
LDCM0388 | CL118 | HEK-293T | C58(0.89) | LDD1592 | [1] |
LDCM0389 | CL119 | HEK-293T | C58(1.36) | LDD1593 | [1] |
LDCM0393 | CL122 | HEK-293T | C58(0.98) | LDD1597 | [1] |
LDCM0394 | CL123 | HEK-293T | C58(0.99) | LDD1598 | [1] |
LDCM0397 | CL126 | HEK-293T | C58(0.96) | LDD1601 | [1] |
LDCM0398 | CL127 | HEK-293T | C58(1.18) | LDD1602 | [1] |
LDCM0401 | CL14 | HEK-293T | C58(0.88) | LDD1605 | [1] |
LDCM0402 | CL15 | HEK-293T | C58(1.26) | LDD1606 | [1] |
LDCM0404 | CL17 | HEK-293T | C58(0.90) | LDD1608 | [1] |
LDCM0407 | CL2 | HEK-293T | C58(0.87) | LDD1611 | [1] |
LDCM0409 | CL21 | HEK-293T | C19(1.05) | LDD1613 | [1] |
LDCM0411 | CL23 | HEK-293T | C58(1.09) | LDD1615 | [1] |
LDCM0414 | CL26 | HEK-293T | C58(1.13) | LDD1618 | [1] |
LDCM0415 | CL27 | HEK-293T | C58(0.95) | LDD1619 | [1] |
LDCM0417 | CL29 | HEK-293T | C58(0.97) | LDD1621 | [1] |
LDCM0418 | CL3 | HEK-293T | C58(1.00) | LDD1622 | [1] |
LDCM0422 | CL33 | HEK-293T | C19(1.04) | LDD1626 | [1] |
LDCM0424 | CL35 | HEK-293T | C58(1.23) | LDD1628 | [1] |
LDCM0428 | CL39 | HEK-293T | C58(1.16) | LDD1632 | [1] |
LDCM0431 | CL41 | HEK-293T | C58(0.89) | LDD1635 | [1] |
LDCM0435 | CL45 | HEK-293T | C19(1.10) | LDD1639 | [1] |
LDCM0437 | CL47 | HEK-293T | C58(1.70) | LDD1641 | [1] |
LDCM0440 | CL5 | HEK-293T | C58(0.96) | LDD1644 | [1] |
LDCM0441 | CL50 | HEK-293T | C58(0.89) | LDD1645 | [1] |
LDCM0444 | CL53 | HEK-293T | C58(0.81) | LDD1647 | [1] |
LDCM0448 | CL57 | HEK-293T | C19(1.11) | LDD1651 | [1] |
LDCM0450 | CL59 | HEK-293T | C58(1.04) | LDD1653 | [1] |
LDCM0454 | CL62 | HEK-293T | C58(0.90) | LDD1657 | [1] |
LDCM0455 | CL63 | HEK-293T | C58(0.86) | LDD1658 | [1] |
LDCM0457 | CL65 | HEK-293T | C58(1.09) | LDD1660 | [1] |
LDCM0461 | CL69 | HEK-293T | C19(1.15) | LDD1664 | [1] |
LDCM0464 | CL71 | HEK-293T | C58(0.87) | LDD1667 | [1] |
LDCM0467 | CL74 | HEK-293T | C58(1.02) | LDD1670 | [1] |
LDCM0470 | CL77 | HEK-293T | C58(0.93) | LDD1673 | [1] |
LDCM0475 | CL81 | HEK-293T | C19(1.16) | LDD1678 | [1] |
LDCM0477 | CL83 | HEK-293T | C58(1.06) | LDD1680 | [1] |
LDCM0480 | CL86 | HEK-293T | C58(1.01) | LDD1683 | [1] |
LDCM0481 | CL87 | HEK-293T | C58(1.07) | LDD1684 | [1] |
LDCM0483 | CL89 | HEK-293T | C58(0.82) | LDD1686 | [1] |
LDCM0484 | CL9 | HEK-293T | C19(1.12) | LDD1687 | [1] |
LDCM0488 | CL93 | HEK-293T | C19(1.10) | LDD1691 | [1] |
LDCM0490 | CL95 | HEK-293T | C58(1.07) | LDD1693 | [1] |
LDCM0493 | CL98 | HEK-293T | C58(1.02) | LDD1696 | [1] |
LDCM0494 | CL99 | HEK-293T | C58(1.17) | LDD1697 | [1] |
LDCM0495 | E2913 | HEK-293T | C58(1.26) | LDD1698 | [1] |
LDCM0468 | Fragment33 | HEK-293T | C58(1.22) | LDD1671 | [1] |
LDCM0427 | Fragment51 | HEK-293T | C58(1.13) | LDD1631 | [1] |
The Interaction Atlas With This Target
The Protein(s) Related To This Target
Enzyme
Transporter and channel
Transcription factor
Other
References