Details of the Target

General Information of Target

Target ID LDTP11688
Target Name NUAK family SNF1-like kinase 2 (NUAK2)
Gene Name NUAK2
Gene ID 81788
Synonyms
OMPHK2; SNARK; NUAK family SNF1-like kinase 2; EC 2.7.11.1; Omphalocele kinase 2; SNF1/AMP kinase-related kinase; SNARK
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGRRRAPAGGSLGRALMRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLD
DFLATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWN
QNTTPEELKQAEKDNFLEWRRQLVRLEEEQKLILTPFERNLDFWRQLWRVIERSDIVVQI
VDARNPLLFRCEDLECYVKEMDANKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWS
ALAGAIPLNGDSEEEANRDDRQSNTTKFGHSSFDQAEISHSESEHLPARDSPSLSENPTT
DEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNF
SHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMGNKKVSVSATPGH
TKHFQTLYVEPGLCLCDCPGLVMPSFVSTKAEMTCSGILPIDQMRDHVPPVSLVCQNIPR
HVLEATYGINIITPREDEDPHRPPTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYV
SGKLLYCHPPPGRDPVTFQHQHQRLLENKMNSDEIKMQLGRNKKAKQIENIVDKTFFHQE
NVRALTKGVQAVMGYKPGSGVVTASTASSENGAGKPWKKHGNRNKKEKSRRLYKHLDM
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
Function
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway.
TTD ID
T55005
Uniprot ID
Q9H093
DrugMap ID
TTHVOTQ
Ensemble ID
ENST00000367157.6
HGNC ID
HGNC:29558
ChEMBL ID
CHEMBL5698

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C351(0.48)  LDD2182  [1]
DBIA
 Probe Info  		C351(3.48)  LDD2236  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C351(0.78)  LDD2187  [1]
 LDCM0572  Fragment10 Ramos C351(1.02)  LDD2189  [1]
 LDCM0573  Fragment11 Ramos C351(0.12)  LDD2190  [1]
 LDCM0574  Fragment12 Ramos C351(1.82)  LDD2191  [1]
 LDCM0575  Fragment13 Ramos C351(0.50)  LDD2192  [1]
 LDCM0576  Fragment14 Ramos C351(1.11)  LDD2193  [1]
 LDCM0579  Fragment20 Ramos C351(1.83)  LDD2194  [1]
 LDCM0580  Fragment21 Ramos C351(0.71)  LDD2195  [1]
 LDCM0582  Fragment23 Ramos C351(1.57)  LDD2196  [1]
 LDCM0578  Fragment27 Ramos C351(1.60)  LDD2197  [1]
 LDCM0586  Fragment28 Ramos C351(0.34)  LDD2198  [1]
 LDCM0588  Fragment30 Ramos C351(1.90)  LDD2199  [1]
 LDCM0589  Fragment31 Ramos C351(1.01)  LDD2200  [1]
 LDCM0590  Fragment32 Ramos C351(3.01)  LDD2201  [1]
 LDCM0468  Fragment33 Ramos C351(1.01)  LDD2202  [1]
 LDCM0596  Fragment38 Ramos C351(1.23)  LDD2203  [1]
 LDCM0566  Fragment4 Ramos C351(1.01)  LDD2184  [1]
 LDCM0610  Fragment52 Ramos C351(0.89)  LDD2204  [1]
 LDCM0614  Fragment56 Ramos C351(0.90)  LDD2205  [1]
 LDCM0569  Fragment7 Ramos C351(0.46)  LDD2186  [1]
 LDCM0571  Fragment9 Ramos C351(1.44)  LDD2188  [1]
 LDCM0022  KB02 Ramos C351(0.48)  LDD2182  [1]
 LDCM0023  KB03 MDA-MB-231 C351(3.90)  LDD1701  [4]
 LDCM0024  KB05 Ramos C351(0.92)  LDD2185  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
GRIP1-associated protein 1 (GRIPAP1) . Q4V328

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bempedoic Acid Small molecular drug DB11936
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Wz4003 Small molecular drug D00HLW

References

1 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
2 Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nat Methods. 2022 Mar;19(3):341-352. doi: 10.1038/s41592-022-01398-2. Epub 2022 Feb 28.
Mass spectrometry data entry: PXD026730
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761