Details of the Target

General Information of Target

Target ID LDTP11621
Target Name Class E basic helix-loop-helix protein 41 (BHLHE41)
Gene Name BHLHE41
Gene ID 79365
Synonyms
BHLHB3; DEC2; SHARP1; Class E basic helix-loop-helix protein 41; bHLHe41; Class B basic helix-loop-helix protein 3; bHLHb3; Differentially expressed in chondrocytes protein 2; hDEC2; Enhancer-of-split and hairy-related protein 1; SHARP-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYN
PSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKC
PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTAD
HGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERIL
RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG
NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH
VGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLL
PGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEE
VMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAE
IEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQG
FQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQG
PPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQ
GPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLN
PRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPP
PQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPI
PFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSR
GPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFH
PDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGR
RPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASE
EAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPR
PDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGK
GRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMN
SGPPRRGASRGGGRGR
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 AND CYP3A11.
Uniprot ID
Q9C0J9
Ensemble ID
ENST00000242728.5
HGNC ID
HGNC:16617

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C203(3.57)  LDD3365  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0259  AC14 HEK-293T C30(1.28)  LDD1512  [2]
 LDCM0282  AC22 HEK-293T C30(1.25)  LDD1521  [2]
 LDCM0291  AC30 HEK-293T C30(1.10)  LDD1530  [2]
 LDCM0299  AC38 HEK-293T C30(1.19)  LDD1538  [2]
 LDCM0308  AC46 HEK-293T C30(1.00)  LDD1547  [2]
 LDCM0317  AC54 HEK-293T C30(1.01)  LDD1556  [2]
 LDCM0323  AC6 HEK-293T C30(0.99)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C30(1.00)  LDD1565  [2]
 LDCM0367  CL1 HEK-293T C63(0.88)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C30(1.28)  LDD1572  [2]
 LDCM0370  CL101 HEK-293T C63(0.81)  LDD1574  [2]
 LDCM0374  CL105 HEK-293T C63(0.80)  LDD1578  [2]
 LDCM0378  CL109 HEK-293T C63(0.85)  LDD1582  [2]
 LDCM0383  CL113 HEK-293T C63(0.96)  LDD1587  [2]
 LDCM0387  CL117 HEK-293T C63(0.79)  LDD1591  [2]
 LDCM0392  CL121 HEK-293T C63(0.75)  LDD1596  [2]
 LDCM0396  CL125 HEK-293T C63(0.75)  LDD1600  [2]
 LDCM0400  CL13 HEK-293T C63(0.85)  LDD1604  [2]
 LDCM0410  CL22 HEK-293T C30(1.42)  LDD1614  [2]
 LDCM0413  CL25 HEK-293T C63(0.76)  LDD1617  [2]
 LDCM0423  CL34 HEK-293T C30(1.04)  LDD1627  [2]
 LDCM0426  CL37 HEK-293T C63(0.89)  LDD1630  [2]
 LDCM0436  CL46 HEK-293T C30(1.31)  LDD1640  [2]
 LDCM0439  CL49 HEK-293T C63(0.81)  LDD1643  [2]
 LDCM0449  CL58 HEK-293T C30(1.32)  LDD1652  [2]
 LDCM0453  CL61 HEK-293T C63(0.82)  LDD1656  [2]
 LDCM0463  CL70 HEK-293T C30(1.11)  LDD1666  [2]
 LDCM0466  CL73 HEK-293T C63(0.80)  LDD1669  [2]
 LDCM0476  CL82 HEK-293T C30(1.53)  LDD1679  [2]
 LDCM0479  CL85 HEK-293T C63(0.83)  LDD1682  [2]
 LDCM0489  CL94 HEK-293T C30(1.40)  LDD1692  [2]
 LDCM0492  CL97 HEK-293T C63(1.01)  LDD1695  [2]
 LDCM0022  KB02 A2058 C71(1.88)  LDD2253  [1]
 LDCM0023  KB03 A2058 C71(3.36)  LDD2670  [1]
 LDCM0024  KB05 OVCAR-3 C203(3.57)  LDD3365  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402