Details of the Target

General Information of Target

Target ID LDTP11618
Target Name Thrombospondin type-1 domain-containing protein 7B (THSD7B)
Gene Name THSD7B
Gene ID 80731
Synonyms
KIAA1679; Thrombospondin type-1 domain-containing protein 7B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGKGVVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEVTLHLLPGEQLLCEASTVLK
YVQEDSCQHGVYGRLVCTDFKIAFLGDDESALDNDETQFKNKVIGENDITLHCVDQIYGV
FDEKKKTLFGQLKKYPEKLIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKR
LFLFSYATAAQNNTVTDPKNHTVMFDTLKDWCWELERTKGNMKYKAVSVNEGYKVCERLP
AYFVVPTPLPEENVQRFQGHGIPIWCWSCHNGSALLKMSALPKEQDDGILQIQKSFLDGI
YKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIKWFSLLESS
SWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQLMMDPHCRTRIGFQ
SLIQKEWVMGGHCFLDRCNHLRQNDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVL
SDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWSVQFEPKAQTLLKNPL
YVEKPKLDKGQRKGMRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLIN
SSDELQDNFREFYDSWHSKSTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGQVAT
LSKLLEMMEEVQSLQEKIDERHHSQQAPQAEAPCLLRNSARLSSLFPFALLQRHSSKPVL
PTSGWKALGDEDDLAKREDEFVDLGDV
Target Bioclass
Other
Subcellular location
Membrane
Uniprot ID
Q9C0I4
Ensemble ID
ENST00000409968.6
HGNC ID
HGNC:29348

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		C883(0.00); C887(0.00)  LDD0241  [1]
DBIA
 Probe Info  		C959(0.90)  LDD1508  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [3]
N1
 Probe Info  		N.A.  LDD0245  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C959(0.90)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C959(1.02)  LDD1509  [2]
 LDCM0237  AC12 HEK-293T C959(0.91)  LDD1510  [2]
 LDCM0277  AC18 HEK-293T C959(1.12)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C959(1.02)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C959(1.08)  LDD1518  [2]
 LDCM0280  AC20 HEK-293T C959(0.92)  LDD1519  [2]
 LDCM0286  AC26 HEK-293T C959(0.88)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C959(1.14)  LDD1526  [2]
 LDCM0288  AC28 HEK-293T C959(0.93)  LDD1527  [2]
 LDCM0290  AC3 HEK-293T C959(0.97)  LDD1529  [2]
 LDCM0295  AC34 HEK-293T C959(0.98)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C959(1.02)  LDD1535  [2]
 LDCM0297  AC36 HEK-293T C959(1.04)  LDD1536  [2]
 LDCM0301  AC4 HEK-293T C959(1.01)  LDD1540  [2]
 LDCM0304  AC42 HEK-293T C959(1.02)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C959(1.04)  LDD1544  [2]
 LDCM0306  AC44 HEK-293T C959(1.11)  LDD1545  [2]
 LDCM0313  AC50 HEK-293T C959(1.14)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C959(1.11)  LDD1553  [2]
 LDCM0315  AC52 HEK-293T C959(1.06)  LDD1554  [2]
 LDCM0321  AC58 HEK-293T C959(1.01)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C959(1.07)  LDD1561  [2]
 LDCM0324  AC60 HEK-293T C959(0.95)  LDD1563  [2]
 LDCM0405  CL18 HEK-293T C959(1.12)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C959(1.08)  LDD1610  [2]
 LDCM0408  CL20 HEK-293T C959(0.98)  LDD1612  [2]
 LDCM0419  CL30 HEK-293T C959(1.05)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C959(1.02)  LDD1624  [2]
 LDCM0421  CL32 HEK-293T C959(0.92)  LDD1625  [2]
 LDCM0432  CL42 HEK-293T C959(0.91)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C959(1.08)  LDD1637  [2]
 LDCM0434  CL44 HEK-293T C959(0.94)  LDD1638  [2]
 LDCM0445  CL54 HEK-293T C959(0.90)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C959(1.05)  LDD1649  [2]
 LDCM0447  CL56 HEK-293T C959(1.02)  LDD1650  [2]
 LDCM0451  CL6 HEK-293T C959(1.09)  LDD1654  [2]
 LDCM0458  CL66 HEK-293T C959(1.09)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C959(1.04)  LDD1662  [2]
 LDCM0460  CL68 HEK-293T C959(0.87)  LDD1663  [2]
 LDCM0462  CL7 HEK-293T C959(1.02)  LDD1665  [2]
 LDCM0471  CL78 HEK-293T C959(0.88)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C959(1.00)  LDD1675  [2]
 LDCM0473  CL8 HEK-293T C959(0.99)  LDD1676  [2]
 LDCM0474  CL80 HEK-293T C959(0.93)  LDD1677  [2]
 LDCM0485  CL90 HEK-293T C959(0.97)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C959(1.10)  LDD1689  [2]
 LDCM0487  CL92 HEK-293T C959(0.86)  LDD1690  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aspartate--tRNA ligase, mitochondrial (DARS2) Class-II aminoacyl-tRNA synthetase family Q6PI48
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) PIGP family P57054
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Peptidyl-prolyl cis-trans isomerase FKBP7 (FKBP7) . Q9Y680
Transporter and channel
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stomatin (STOM) Band 7/mec-2 family P27105
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Gap junction alpha-8 protein (GJA8) Connexin family P48165
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Hippocampus abundant transcript-like protein 1 (MFSD14B) Major facilitator superfamily Q5SR56
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1) . Q9Y5Y7
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G-protein coupled receptor 37-like 1 (GPR37L1) G-protein coupled receptor 1 family O60883
Probable G-protein coupled receptor 101 (GPR101) G-protein coupled receptor 1 family Q96P66
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 3DL1 (KIR3DL1) Immunoglobulin superfamily P43629
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Translation initiation factor IF-3, mitochondrial (MTIF3) IF-3 family Q9H2K0
Synaptotagmin-2 (SYT2) Synaptotagmin family Q8N9I0
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) . Q53GL0
Sperm acrosome membrane-associated protein 1 (SPACA1) . Q9HBV2

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.