Details of the Target

General Information of Target

Target ID LDTP11616
Target Name SRC kinase signaling inhibitor 1 (SRCIN1)
Gene Name SRCIN1
Gene ID 80725
Synonyms
KIAA1684; P140; SNIP; SRC kinase signaling inhibitor 1; SNAP-25-interacting protein; SNIP; p130Cas-associated protein; p140Cap
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGVSYAAPWWVSLLHRLPHFDLSWEATSSQFRPEDTDYQQALLLLGAAALACLALDLLF
LLFYSFWLCCRRRKSEEHLDADCCCTAWCVIIATLVCSAGIAVGFYGNGETSDGIHRATY
SLRHANRTVAGVQDRVWDTAVGLNHTAEPSLQTLERQLAGRPEPLRAVQRLQGLLETLLG
YTAAIPFWRNTAVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILV
GVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDAYVTKMVEEYSVLSGDILQYYLACS
PRAANPFQQKLSGSHKALVEMQDVVAELLRTVPWEQPATKDPLLRVQEVLNGTEVNLQHL
TALVDCRSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSVPHTWQQKRGPD
EDGEEEAAPGPRQAHDSLYRVHMPSLYSCGSSYGSETSIPAAAHTVSNAPVTEYMSQNAN
FQNPRCENTPLIGRESPPPSYTSSMRAKYLATSQPRPDSSGSH
Target Bioclass
Other
Family
SRCIN1 family
Subcellular location
Cytoplasm
Function
Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
Uniprot ID
Q9C0H9
Ensemble ID
ENST00000615049.4
HGNC ID
HGNC:29506
ChEMBL ID
CHEMBL2150836

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C950(3.07)  LDD3340  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0226  AC11 HEK-293T C950(0.94)  LDD1509  [3]
 LDCM0259  AC14 HEK-293T C950(1.00)  LDD1512  [3]
 LDCM0278  AC19 HEK-293T C950(0.79)  LDD1517  [3]
 LDCM0281  AC21 HEK-293T C950(0.94)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C950(0.91)  LDD1521  [3]
 LDCM0287  AC27 HEK-293T C950(1.06)  LDD1526  [3]
 LDCM0289  AC29 HEK-293T C950(0.95)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C950(0.87)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C950(0.99)  LDD1530  [3]
 LDCM0296  AC35 HEK-293T C950(0.84)  LDD1535  [3]
 LDCM0298  AC37 HEK-293T C950(1.06)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C950(1.00)  LDD1538  [3]
 LDCM0305  AC43 HEK-293T C950(1.00)  LDD1544  [3]
 LDCM0307  AC45 HEK-293T C950(0.97)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C950(1.00)  LDD1547  [3]
 LDCM0312  AC5 HEK-293T C950(1.02)  LDD1551  [3]
 LDCM0314  AC51 HEK-293T C950(1.00)  LDD1553  [3]
 LDCM0316  AC53 HEK-293T C950(1.23)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C950(0.96)  LDD1556  [3]
 LDCM0322  AC59 HEK-293T C950(0.99)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C950(1.02)  LDD1562  [3]
 LDCM0325  AC61 HEK-293T C950(1.05)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C950(1.06)  LDD1565  [3]
 LDCM0248  AKOS034007472 HEK-293T C950(1.04)  LDD1511  [3]
 LDCM0368  CL10 HEK-293T C950(1.11)  LDD1572  [3]
 LDCM0371  CL102 HEK-293T C950(0.98)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C950(1.10)  LDD1576  [3]
 LDCM0375  CL106 HEK-293T C950(1.01)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C950(1.11)  LDD1580  [3]
 LDCM0380  CL110 HEK-293T C950(0.99)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C950(0.98)  LDD1585  [3]
 LDCM0384  CL114 HEK-293T C950(0.96)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C950(1.05)  LDD1589  [3]
 LDCM0388  CL118 HEK-293T C950(0.99)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C950(1.07)  LDD1593  [3]
 LDCM0393  CL122 HEK-293T C950(0.89)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C950(1.12)  LDD1598  [3]
 LDCM0397  CL126 HEK-293T C950(1.01)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C950(1.10)  LDD1602  [3]
 LDCM0401  CL14 HEK-293T C950(0.94)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C950(1.13)  LDD1606  [3]
 LDCM0406  CL19 HEK-293T C950(0.90)  LDD1610  [3]
 LDCM0407  CL2 HEK-293T C950(0.92)  LDD1611  [3]
 LDCM0409  CL21 HEK-293T C950(1.06)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C950(1.03)  LDD1614  [3]
 LDCM0414  CL26 HEK-293T C950(0.96)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C950(1.11)  LDD1619  [3]
 LDCM0418  CL3 HEK-293T C950(1.10)  LDD1622  [3]
 LDCM0420  CL31 HEK-293T C950(0.95)  LDD1624  [3]
 LDCM0422  CL33 HEK-293T C950(0.97)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C950(1.14)  LDD1627  [3]
 LDCM0428  CL39 HEK-293T C950(1.13)  LDD1632  [3]
 LDCM0433  CL43 HEK-293T C950(1.00)  LDD1637  [3]
 LDCM0435  CL45 HEK-293T C950(0.65)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C950(1.00)  LDD1640  [3]
 LDCM0441  CL50 HEK-293T C950(1.05)  LDD1645  [3]
 LDCM0446  CL55 HEK-293T C950(0.91)  LDD1649  [3]
 LDCM0448  CL57 HEK-293T C950(1.46)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C950(1.15)  LDD1652  [3]
 LDCM0454  CL62 HEK-293T C950(0.94)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C950(1.25)  LDD1658  [3]
 LDCM0459  CL67 HEK-293T C950(0.93)  LDD1662  [3]
 LDCM0461  CL69 HEK-293T C950(1.11)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C950(0.96)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C950(0.97)  LDD1666  [3]
 LDCM0467  CL74 HEK-293T C950(0.92)  LDD1670  [3]
 LDCM0472  CL79 HEK-293T C950(0.87)  LDD1675  [3]
 LDCM0475  CL81 HEK-293T C950(0.97)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C950(1.09)  LDD1679  [3]
 LDCM0480  CL86 HEK-293T C950(0.97)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C950(1.15)  LDD1684  [3]
 LDCM0484  CL9 HEK-293T C950(1.31)  LDD1687  [3]
 LDCM0486  CL91 HEK-293T C950(1.02)  LDD1689  [3]
 LDCM0488  CL93 HEK-293T C950(0.94)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C950(1.06)  LDD1692  [3]
 LDCM0493  CL98 HEK-293T C950(0.96)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C950(1.03)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C950(1.16)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C950(1.07)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C950(0.95)  LDD1631  [3]
 LDCM0022  KB02 BRX211 C950(2.19)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C950(3.46)  LDD2685  [1]
 LDCM0024  KB05 NB1 C950(3.07)  LDD3340  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402