Details of the Target

General Information of Target

Target ID LDTP11521
Target Name Cytoplasmic polyadenylation element-binding protein 1 (CPEB1)
Gene Name CPEB1
Gene ID 64506
Synonyms
CPEB; Cytoplasmic polyadenylation element-binding protein 1; CPE-BP1; CPE-binding protein 1; h-CPEB; hCPEB-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFRVGFLIISSSSSLSPLLLVSVVRVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNY
TIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTG
ARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISI
PENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELD
REEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSV
TQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVL
ASDGGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDK
DADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQ
SAMLFIKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPD
APPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSP
VFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPN
ISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPS
TNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHR
VLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTS
DYVKILVAAVAGTITVVVVIFITAVVRCRQAPHLKAAQKNMQNSEWATPNPENRQMIMMK
KKKKKKKHSPKNLLLNVVTIEETKADDVDSDGNRVTLDLPIDLEEQTMGKYNWVTTPTTF
KPDSPDLARHYKSASPQPAFQIQPETPLNLKHHIIQELPLDNTFVACDSISNCSSSSSDP
YSVSDCGYPVTTFEVPVSVHTRPSQRRVTFHLPEGSQESSSDGGLGDHDAGSLTSTSHGL
PLGYPQEEYFDRATPSNRTEGDGNSDPESTFIPGLKKEITVQPTVEEASDNCTQECLIYG
HSDACWMPASLDHSSSSQAQASALCHSPPLSQASTQHHSPPVTQTIVLCHSPPVTQTIAL
CHSPPPIQVSALHHSPPLVQGTALHHSPPSAQASALCYSPPLAQAAAISHSSSLPQVIAL
HRSQAQSSVSLQQGWVQGANGLCSVDQGVQGSATSQFYTMSERLHPSDDSIKVIPLTTFA
PRQQARPSRGDSPIMETHPL
Target Bioclass
Other
Family
RRM CPEB family
Subcellular location
Cytoplasm
Function
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry.
Uniprot ID
Q9BZB8
Ensemble ID
ENST00000611163.4
HGNC ID
HGNC:21744

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C50(6.50)  LDD0204  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C50(0.95)  LDD1507  [2]
 LDCM0276  AC17 HEK-293T C50(0.86)  LDD1515  [2]
 LDCM0285  AC25 HEK-293T C50(0.92)  LDD1524  [2]
 LDCM0294  AC33 HEK-293T C50(0.98)  LDD1533  [2]
 LDCM0303  AC41 HEK-293T C50(1.01)  LDD1542  [2]
 LDCM0311  AC49 HEK-293T C50(0.92)  LDD1550  [2]
 LDCM0320  AC57 HEK-293T C50(0.96)  LDD1559  [2]
 LDCM0356  AKOS034007680 HEK-293T C50(0.90)  LDD1570  [2]
 LDCM0102  BDHI 8 Jurkat C50(6.50)  LDD0204  [1]
 LDCM0367  CL1 HEK-293T C50(0.92)  LDD1571  [2]
 LDCM0370  CL101 HEK-293T C50(0.85)  LDD1574  [2]
 LDCM0371  CL102 HEK-293T C50(0.97)  LDD1575  [2]
 LDCM0372  CL103 HEK-293T C50(0.97)  LDD1576  [2]
 LDCM0374  CL105 HEK-293T C50(0.78)  LDD1578  [2]
 LDCM0375  CL106 HEK-293T C50(0.93)  LDD1579  [2]
 LDCM0376  CL107 HEK-293T C50(0.87)  LDD1580  [2]
 LDCM0378  CL109 HEK-293T C50(0.81)  LDD1582  [2]
 LDCM0380  CL110 HEK-293T C50(1.14)  LDD1584  [2]
 LDCM0381  CL111 HEK-293T C50(0.88)  LDD1585  [2]
 LDCM0383  CL113 HEK-293T C50(0.91)  LDD1587  [2]
 LDCM0384  CL114 HEK-293T C50(1.07)  LDD1588  [2]
 LDCM0385  CL115 HEK-293T C50(0.80)  LDD1589  [2]
 LDCM0387  CL117 HEK-293T C50(1.04)  LDD1591  [2]
 LDCM0388  CL118 HEK-293T C50(1.08)  LDD1592  [2]
 LDCM0389  CL119 HEK-293T C50(0.98)  LDD1593  [2]
 LDCM0392  CL121 HEK-293T C50(0.97)  LDD1596  [2]
 LDCM0393  CL122 HEK-293T C50(1.08)  LDD1597  [2]
 LDCM0394  CL123 HEK-293T C50(1.21)  LDD1598  [2]
 LDCM0396  CL125 HEK-293T C50(0.87)  LDD1600  [2]
 LDCM0397  CL126 HEK-293T C50(0.86)  LDD1601  [2]
 LDCM0398  CL127 HEK-293T C50(1.14)  LDD1602  [2]
 LDCM0400  CL13 HEK-293T C50(0.95)  LDD1604  [2]
 LDCM0401  CL14 HEK-293T C50(0.87)  LDD1605  [2]
 LDCM0402  CL15 HEK-293T C50(1.03)  LDD1606  [2]
 LDCM0404  CL17 HEK-293T C50(1.01)  LDD1608  [2]
 LDCM0407  CL2 HEK-293T C50(0.79)  LDD1611  [2]
 LDCM0413  CL25 HEK-293T C50(0.76)  LDD1617  [2]
 LDCM0414  CL26 HEK-293T C50(0.78)  LDD1618  [2]
 LDCM0415  CL27 HEK-293T C50(0.89)  LDD1619  [2]
 LDCM0417  CL29 HEK-293T C50(0.79)  LDD1621  [2]
 LDCM0418  CL3 HEK-293T C50(1.01)  LDD1622  [2]
 LDCM0426  CL37 HEK-293T C50(0.85)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C50(0.86)  LDD1632  [2]
 LDCM0431  CL41 HEK-293T C50(0.88)  LDD1635  [2]
 LDCM0439  CL49 HEK-293T C50(0.76)  LDD1643  [2]
 LDCM0440  CL5 HEK-293T C50(0.78)  LDD1644  [2]
 LDCM0441  CL50 HEK-293T C50(1.05)  LDD1645  [2]
 LDCM0444  CL53 HEK-293T C50(0.83)  LDD1647  [2]
 LDCM0453  CL61 HEK-293T C50(0.92)  LDD1656  [2]
 LDCM0454  CL62 HEK-293T C50(0.88)  LDD1657  [2]
 LDCM0455  CL63 HEK-293T C50(0.94)  LDD1658  [2]
 LDCM0457  CL65 HEK-293T C50(1.02)  LDD1660  [2]
 LDCM0466  CL73 HEK-293T C50(0.89)  LDD1669  [2]
 LDCM0467  CL74 HEK-293T C50(0.76)  LDD1670  [2]
 LDCM0470  CL77 HEK-293T C50(1.12)  LDD1673  [2]
 LDCM0479  CL85 HEK-293T C50(0.83)  LDD1682  [2]
 LDCM0480  CL86 HEK-293T C50(0.96)  LDD1683  [2]
 LDCM0481  CL87 HEK-293T C50(0.91)  LDD1684  [2]
 LDCM0483  CL89 HEK-293T C50(0.89)  LDD1686  [2]
 LDCM0492  CL97 HEK-293T C50(0.91)  LDD1695  [2]
 LDCM0493  CL98 HEK-293T C50(0.96)  LDD1696  [2]
 LDCM0494  CL99 HEK-293T C50(0.95)  LDD1697  [2]
 LDCM0495  E2913 HEK-293T C50(0.83)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C50(0.81)  LDD1671  [2]
 LDCM0427  Fragment51 HEK-293T C50(0.86)  LDD1631  [2]
 LDCM0022  KB02 IPC-298 C50(2.36)  LDD2400  [3]
 LDCM0023  KB03 IPC-298 C50(2.82)  LDD2817  [3]
 LDCM0024  KB05 RVH-421 C50(1.44)  LDD3413  [3]

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840