Details of the Target

General Information of Target

Target ID LDTP11512
Target Name Disintegrin and metalloproteinase domain-containing protein 33 (ADAM33)
Gene Name ADAM33
Gene ID 80332
Synonyms
C20orf153; Disintegrin and metalloproteinase domain-containing protein 33; ADAM 33; EC 3.4.24.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASRSMRLLLLLSCLAKTGVLGDIIMRPSCAPGWFYHKSNCYGYFRKLRNWSDAELECQS
YGNGAHLASILSLKEASTIAEYISGYQRSQPIWIGLHDPQKRQQWQWIDGAMYLYRSWSG
KSMGGNKHCAEMSSNNNFLTWSSNECNKRQHFLCKYRP
Target Type
Patented-recorded
Target Bioclass
Enzyme
Subcellular location
Membrane
TTD ID
T11192
Uniprot ID
Q9BZ11
DrugMap ID
TTQICM2
Ensemble ID
ENST00000350009.6
HGNC ID
HGNC:15478
ChEMBL ID
CHEMBL6121

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E73K .
CAL51 Deletion: p.A455PfsTer14 .
CMK SNV: p.Q284H .
HCT15 SNV: p.A146D .
JURKAT SNV: p.G621D .
MOLT4 SNV: p.A72V .
NCIH1048 SNV: p.H232R .
NCIH1793 SNV: p.Q557K .
OCIAML2 SNV: p.T701P .
PEO1 SNV: p.P497Q .
RCC10RGB SNV: p.A571T .
SUPT1 SNV: p.A375V .
SW1271 SNV: p.S493Y .
SW1990 SNV: p.A28S .
TOV21G SNV: p.Q254H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C578(0.85)  LDD2100  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C578(0.70)  LDD2112  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C578(0.85)  LDD2100  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C578(0.79)  LDD2104  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C578(0.52)  LDD2114  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C578(1.93)  LDD2145  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761