Details of the Target

General Information of Target

Target ID LDTP11376
Target Name Bcl-2-binding component 3, isoforms 1/2 (BBC3)
Gene Name BBC3
Gene ID 27113
Synonyms
PUMA; Bcl-2-binding component 3, isoforms 1/2; JFY-1; p53 up-regulated modulator of apoptosis
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERVGCTLTTTYAHPRPTPTNFLPAISTMASSYRDRFPHSNLTHSLSLPWRPSTYYKVAS
NSPSVAPYCTRSQRVSENTMLPFVSNRTTFFTRYTPDDWYRSNLTNYQESNTSRHNSEKL
RVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEIIHELDEMIGETNALTDVKKR
LERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQLLTEVDTILCCQERMKLHLDKA
IAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRNTSDGVGYFRGVERVDATVSVPESW
AKFTDDNILRSQSERAASAKLRDDIENLLVVTANEMWNQFNKVNLSFTNRIAETADAKNK
IQTHLAKTLQEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERTRRPNIELCRDMAQLRL
VNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYIDQEKCMSMRKSY
PNTLRLVGFC
Target Type
Literature-reported
Target Bioclass
Other
Family
Bcl-2 family
Subcellular location
Mitochondrion
Function
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Promotes partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53, releasing the bound p53/TP53 to induce apoptosis. Regulates ER stress-induced neuronal apoptosis.
TTD ID
T21460
Uniprot ID
Q9BXH1
DrugMap ID
TT7JUKC
Ensemble ID
ENST00000341983.8
HGNC ID
HGNC:17868

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.A67T .
JURKAT SNV: p.R127C .
OZ SNV: p.V14A .
SNU1 Deletion: p.A49PfsTer166 .
TC71 SNV: p.S98Ter .
TOV21G SNV: p.R76S .
WM2664 Insertion: p.A2GfsTer227 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C37(0.87)  LDD1507  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C37(0.87)  LDD1507  [1]
 LDCM0259  AC14 HEK-293T C40(0.77)  LDD1512  [1]
 LDCM0276  AC17 HEK-293T C37(1.05)  LDD1515  [1]
 LDCM0282  AC22 HEK-293T C40(1.03)  LDD1521  [1]
 LDCM0285  AC25 HEK-293T C37(1.49)  LDD1524  [1]
 LDCM0291  AC30 HEK-293T C40(0.99)  LDD1530  [1]
 LDCM0294  AC33 HEK-293T C37(1.16)  LDD1533  [1]
 LDCM0299  AC38 HEK-293T C40(0.94)  LDD1538  [1]
 LDCM0303  AC41 HEK-293T C37(1.28)  LDD1542  [1]
 LDCM0308  AC46 HEK-293T C40(1.22)  LDD1547  [1]
 LDCM0311  AC49 HEK-293T C37(1.50)  LDD1550  [1]
 LDCM0317  AC54 HEK-293T C40(0.87)  LDD1556  [1]
 LDCM0320  AC57 HEK-293T C37(0.95)  LDD1559  [1]
 LDCM0323  AC6 HEK-293T C40(0.76)  LDD1562  [1]
 LDCM0326  AC62 HEK-293T C40(0.91)  LDD1565  [1]
 LDCM0356  AKOS034007680 HEK-293T C37(0.90)  LDD1570  [1]
 LDCM0367  CL1 HEK-293T C40(1.34)  LDD1571  [1]
 LDCM0368  CL10 HEK-293T C40(0.86)  LDD1572  [1]
 LDCM0370  CL101 HEK-293T C40(1.24)  LDD1574  [1]
 LDCM0374  CL105 HEK-293T C40(1.18)  LDD1578  [1]
 LDCM0378  CL109 HEK-293T C40(1.35)  LDD1582  [1]
 LDCM0383  CL113 HEK-293T C40(1.05)  LDD1587  [1]
 LDCM0387  CL117 HEK-293T C40(1.22)  LDD1591  [1]
 LDCM0392  CL121 HEK-293T C40(1.38)  LDD1596  [1]
 LDCM0396  CL125 HEK-293T C40(1.22)  LDD1600  [1]
 LDCM0400  CL13 HEK-293T C40(1.13)  LDD1604  [1]
 LDCM0404  CL17 HEK-293T C37(1.00)  LDD1608  [1]
 LDCM0410  CL22 HEK-293T C40(0.98)  LDD1614  [1]
 LDCM0413  CL25 HEK-293T C40(1.33)  LDD1617  [1]
 LDCM0417  CL29 HEK-293T C37(0.87)  LDD1621  [1]
 LDCM0423  CL34 HEK-293T C40(1.00)  LDD1627  [1]
 LDCM0426  CL37 HEK-293T C40(1.25)  LDD1630  [1]
 LDCM0431  CL41 HEK-293T C37(1.76)  LDD1635  [1]
 LDCM0436  CL46 HEK-293T C40(0.86)  LDD1640  [1]
 LDCM0439  CL49 HEK-293T C40(1.06)  LDD1643  [1]
 LDCM0440  CL5 HEK-293T C37(1.00)  LDD1644  [1]
 LDCM0444  CL53 HEK-293T C37(1.15)  LDD1647  [1]
 LDCM0449  CL58 HEK-293T C40(0.98)  LDD1652  [1]
 LDCM0453  CL61 HEK-293T C40(1.40)  LDD1656  [1]
 LDCM0457  CL65 HEK-293T C37(1.05)  LDD1660  [1]
 LDCM0463  CL70 HEK-293T C40(1.10)  LDD1666  [1]
 LDCM0466  CL73 HEK-293T C40(1.05)  LDD1669  [1]
 LDCM0470  CL77 HEK-293T C37(1.13)  LDD1673  [1]
 LDCM0476  CL82 HEK-293T C40(1.02)  LDD1679  [1]
 LDCM0479  CL85 HEK-293T C40(1.02)  LDD1682  [1]
 LDCM0483  CL89 HEK-293T C37(1.15)  LDD1686  [1]
 LDCM0489  CL94 HEK-293T C40(1.20)  LDD1692  [1]
 LDCM0492  CL97 HEK-293T C40(1.36)  LDD1695  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402