Details of the Target

General Information of Target

Target ID LDTP11282
Target Name E3 ubiquitin-protein ligase TRIM62 (TRIM62)
Gene Name TRIM62
Gene ID 55223
Synonyms
E3 ubiquitin-protein ligase TRIM62; EC 2.3.2.27; Tripartite motif-containing protein 62
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAPVDVLTQIGRS
VRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQG
LKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVP
DPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSV
EEE
Target Bioclass
Enzyme
Family
TRIM/RBCC family
Subcellular location
Cytoplasm
Function
E3 ubiquitin ligase that plays a role in antifungal immunity by mediating 'Lys-27'-linked ubiquitination of CARD9 downstream of C-type lectin receptors; leading to CARD9 activation, followed by activation of NF-kappa-B and MAP kinase p38 pathways. E3 ubiquitin ligase activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.
Uniprot ID
Q9BVG3
Ensemble ID
ENST00000291416.10
HGNC ID
HGNC:25574

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.E212K .
HCT15 SNV: p.S383I .
Ishikawa (Heraklio) 02 ER SNV: p.T126A .
JURKAT SNV: p.Y29S .
OVK18 SNV: p.T405M .
SKMEL30 SNV: p.D411N .
SW1116 SNV: p.A90E .
TOV21G SNV: p.P79T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C103(3.58)  LDD3410  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C34(1.09)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C34(1.17)  LDD1508  [3]
 LDCM0259  AC14 HEK-293T C93(0.98)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C34(1.13)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C34(1.01)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C34(0.99)  LDD1518  [3]
 LDCM0282  AC22 HEK-293T C93(0.97)  LDD1521  [3]
 LDCM0285  AC25 HEK-293T C34(1.12)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C34(0.97)  LDD1525  [3]
 LDCM0291  AC30 HEK-293T C93(0.98)  LDD1530  [3]
 LDCM0294  AC33 HEK-293T C34(1.22)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C34(1.00)  LDD1534  [3]
 LDCM0299  AC38 HEK-293T C93(1.11)  LDD1538  [3]
 LDCM0303  AC41 HEK-293T C34(1.16)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C34(1.00)  LDD1543  [3]
 LDCM0308  AC46 HEK-293T C93(1.02)  LDD1547  [3]
 LDCM0311  AC49 HEK-293T C34(1.15)  LDD1550  [3]
 LDCM0313  AC50 HEK-293T C34(1.13)  LDD1552  [3]
 LDCM0317  AC54 HEK-293T C93(0.95)  LDD1556  [3]
 LDCM0320  AC57 HEK-293T C34(1.07)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C34(1.04)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C93(1.08)  LDD1562  [3]
 LDCM0326  AC62 HEK-293T C93(0.95)  LDD1565  [3]
 LDCM0356  AKOS034007680 HEK-293T C34(1.04)  LDD1570  [3]
 LDCM0368  CL10 HEK-293T C93(0.86)  LDD1572  [3]
 LDCM0404  CL17 HEK-293T C34(1.16)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C34(1.11)  LDD1609  [3]
 LDCM0410  CL22 HEK-293T C93(0.80)  LDD1614  [3]
 LDCM0417  CL29 HEK-293T C34(1.17)  LDD1621  [3]
 LDCM0419  CL30 HEK-293T C34(1.11)  LDD1623  [3]
 LDCM0423  CL34 HEK-293T C93(0.76)  LDD1627  [3]
 LDCM0431  CL41 HEK-293T C34(1.16)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C34(1.16)  LDD1636  [3]
 LDCM0436  CL46 HEK-293T C93(0.76)  LDD1640  [3]
 LDCM0440  CL5 HEK-293T C34(1.35)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C34(1.17)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C34(1.10)  LDD1648  [3]
 LDCM0449  CL58 HEK-293T C93(0.80)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C34(1.10)  LDD1654  [3]
 LDCM0457  CL65 HEK-293T C34(1.14)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C34(1.10)  LDD1661  [3]
 LDCM0463  CL70 HEK-293T C93(0.79)  LDD1666  [3]
 LDCM0470  CL77 HEK-293T C34(1.09)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C34(1.00)  LDD1674  [3]
 LDCM0476  CL82 HEK-293T C93(0.85)  LDD1679  [3]
 LDCM0483  CL89 HEK-293T C34(1.10)  LDD1686  [3]
 LDCM0485  CL90 HEK-293T C34(0.92)  LDD1688  [3]
 LDCM0489  CL94 HEK-293T C93(0.84)  LDD1692  [3]
 LDCM0022  KB02 A2058 C103(1.72)  LDD2253  [1]
 LDCM0023  KB03 A2058 C103(2.62)  LDD2670  [1]
 LDCM0024  KB05 RPMI-7951 C103(3.58)  LDD3410  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutaredoxin-1 (GLRX) Glutaredoxin family P35754
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
E3 ubiquitin-protein ligase TRIM62 (TRIM62) TRIM/RBCC family Q9BVG3
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D3 (UBE2D3) Ubiquitin-conjugating enzyme family P61077
Ubiquitin-conjugating enzyme E2 D4 (UBE2D4) Ubiquitin-conjugating enzyme family Q9Y2X8
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4
Ubiquitin/ISG15-conjugating enzyme E2 L6 (UBE2L6) Ubiquitin-conjugating enzyme family O14933
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Sp7 (SP7) Sp1 C2H2-type zinc-finger protein family Q8TDD2
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ELL-associated factor 1 (EAF1) EAF family Q96JC9
U3 small nucleolar RNA-associated protein 25 homolog (UTP25) UTP25 family Q68CQ4
Phostensin (PPP1R18) . Q6NYC8
TBC1 domain family member 7 (TBC1D7) . Q9P0N9
UBX domain-containing protein 7 (UBXN7) . O94888

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402