Details of the Target

General Information of Target

Target ID LDTP11069
Target Name Sclerostin (SOST)
Gene Name SOST
Gene ID 50964
Synonyms
Sclerostin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYLQVETRTSSRLHLKRAPGIRSWSLLVGILSIGLAAAYYSGDSLGWKLFYVTGCLFVAV
QNLEDWEEAIFDKSTGKVVLKTFSLYKKLLTLFRAGHDQVVVLLHDVRDVSVEEEKVRYF
GKGYMVVLRLATGFSHPLTQSAVMGHRSDVEAIAKLITSFLELHCLESPTELSQSSDSEA
GDPASQS
Target Type
Successful
Target Bioclass
Other
Family
Sclerostin family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
TTD ID
T60724
Uniprot ID
Q9BQB4
DrugMap ID
TTYRO4F
Ensemble ID
ENST00000301691.3
HGNC ID
HGNC:13771
ChEMBL ID
CHEMBL3580487

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A202P .
HCT15 SNV: p.A156V .
MOLT4 SNV: p.C105Y .
RKO SNV: p.D32E .
SUPT1 Deletion: p.D137TfsTer112 .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Low-density lipoprotein receptor-related protein 4 (LRP4) LDLR family O75096
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Low-density lipoprotein receptor-related protein 5 (LRP5) LDLR family O75197
Low-density lipoprotein receptor-related protein 6 (LRP6) LDLR family O75581
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Romosozumab Antibody D0K3LO
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bps-804 Antibody D0XY4A
Ly2541546 Antibody D08PKG
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amg 167 . D02DJR

References

1 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.