Details of the Target

General Information of Target

Target ID LDTP11063
Target Name Protein FAM110A (FAM110A)
Gene Name FAM110A
Gene ID 83541
Synonyms
C20orf55; F10; Protein FAM110A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYV
EAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAK
AATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTS
LDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTT
IIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTN
EVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPN
SSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWN
TQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL
Target Bioclass
Other
Family
FAM110 family
Subcellular location
Cytoplasm
Uniprot ID
Q9BQ89
Ensemble ID
ENST00000246100.3
HGNC ID
HGNC:16188

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C209(1.52)  LDD2227  [1]
DBIA
 Probe Info  		C97(1.06)  LDD1508  [2]
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C97(1.06)  LDD1508  [2]
 LDCM0270  AC15 HEK-293T C97(1.03)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C97(1.00)  LDD1516  [2]
 LDCM0279  AC2 HEK-293T C97(1.05)  LDD1518  [2]
 LDCM0283  AC23 HEK-293T C97(1.04)  LDD1522  [2]
 LDCM0286  AC26 HEK-293T C97(1.06)  LDD1525  [2]
 LDCM0292  AC31 HEK-293T C97(1.07)  LDD1531  [2]
 LDCM0295  AC34 HEK-293T C97(0.99)  LDD1534  [2]
 LDCM0300  AC39 HEK-293T C97(1.01)  LDD1539  [2]
 LDCM0304  AC42 HEK-293T C97(1.02)  LDD1543  [2]
 LDCM0309  AC47 HEK-293T C97(1.03)  LDD1548  [2]
 LDCM0313  AC50 HEK-293T C97(1.01)  LDD1552  [2]
 LDCM0318  AC55 HEK-293T C97(0.97)  LDD1557  [2]
 LDCM0321  AC58 HEK-293T C97(1.00)  LDD1560  [2]
 LDCM0327  AC63 HEK-293T C97(1.03)  LDD1566  [2]
 LDCM0334  AC7 HEK-293T C97(0.98)  LDD1568  [2]
 LDCM0632  CL-Sc Hep-G2 C209(1.52)  LDD2227  [1]
 LDCM0379  CL11 HEK-293T C97(1.11)  LDD1583  [2]
 LDCM0405  CL18 HEK-293T C97(1.05)  LDD1609  [2]
 LDCM0411  CL23 HEK-293T C97(1.23)  LDD1615  [2]
 LDCM0419  CL30 HEK-293T C97(1.01)  LDD1623  [2]
 LDCM0424  CL35 HEK-293T C97(1.36)  LDD1628  [2]
 LDCM0432  CL42 HEK-293T C97(1.11)  LDD1636  [2]
 LDCM0437  CL47 HEK-293T C97(1.20)  LDD1641  [2]
 LDCM0445  CL54 HEK-293T C97(1.09)  LDD1648  [2]
 LDCM0450  CL59 HEK-293T C97(1.25)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C97(1.03)  LDD1654  [2]
 LDCM0458  CL66 HEK-293T C97(1.09)  LDD1661  [2]
 LDCM0464  CL71 HEK-293T C97(1.27)  LDD1667  [2]
 LDCM0471  CL78 HEK-293T C97(1.03)  LDD1674  [2]
 LDCM0477  CL83 HEK-293T C97(1.08)  LDD1680  [2]
 LDCM0485  CL90 HEK-293T C97(1.16)  LDD1688  [2]
 LDCM0490  CL95 HEK-293T C97(1.22)  LDD1693  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Casein kinase I isoform epsilon (CSNK1E) CK1 Ser/Thr protein kinase family P49674
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
E3 ubiquitin-protein ligase TRIM69 (TRIM69) TRIM/RBCC family Q86WT6
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myogenin (MYOG) . P15173
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) . Q8NAM6
Other
Click To Hide/Show 31 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-D1-binding protein 1 (CCNDBP1) CCNDBP1 family O95273
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Conserved oligomeric Golgi complex subunit 4 (COG4) COG4 family Q9H9E3
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Reticulocalbin-1 (RCN1) CREC family Q15293
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) Fibulin family Q12805
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha7 (KRT37) Intermediate filament family O76014
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 39 (KRT39) Intermediate filament family Q6A163
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Protein LDOC1 (LDOC1) LDOC1 family O95751
Protein limb expression 1 homolog (LIX1) LIX1 family Q8N485
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Paraneoplastic antigen Ma1 (PNMA1) PNMA family Q8ND90
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Ropporin-1A (ROPN1) Ropporin family Q9HAT0
Syntaxin-11 (STX11) Syntaxin family O75558
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heat shock factor 2-binding protein (HSF2BP) . O75031
Ras association domain-containing protein 10 (RASSF10) . A6NK89
Ras association domain-containing protein 3 (RASSF3) . Q86WH2
SH2/SH3 adapter protein NCK1 (NCK1) . P16333

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019