Details of the Target

General Information of Target

Target ID LDTP10750
Target Name Hedgehog-interacting protein (HHIP)
Gene Name HHIP
Gene ID 64399
Synonyms
HIP; Hedgehog-interacting protein; HHIP; HIP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASEEASLRALESLMTEFFHDCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYV
MMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQ
DWPMFYHDFFTNILQLIQSPVTTPLGLIMLKTTSEELACPREDLSVARKEELRKLLLDQV
QTVLGLLTGILETVWDKHSVTAATPPPSPTSGESGDLLSNLLQSPSSAKLLNQPIPILDV
ESEYICSLALECLAHLFSWIPLSASITPSLLTTIFHFARFGCDIRARKMASVNGSSQNCV
SGQERGRLGVLAMSCINELMSKNCVPMEFEEYLLRMFQQTFYLLQKITKDNNAHTVKSRL
EELDESYIEKFTDFLRLFVSVHLRRIESYSQFPVVEFLTLLFKYTFHQPTHEGYFSCLDI
WTLFLDYLTSKIKSRLGDKEAVLNRYEDALVLLLTEVLNRIQFRYNQAQLEELDDETLDD
DQQTEWQRYLRQSLEVVAKVMELLPTHAFSTLFPVLQDNLEVYLGLQQFIVTSGSGHRLN
ITAENDCRRLHCSLRDLSSLLQAVGRLAEYFIGDVFAARFNDALTVVERLVKVTLYGSQI
KLYNIETAVPSVLKPDLIDVHAQSLAALQAYSHWLAQYCSEVHRQNTQQFVTLISTTMDA
ITPLISTKVQDKLLLSACHLLVSLATTVRPVFLISIPAVQKVFNRITDASALRLVDKAQV
LVCRALSNILLLPWPNLPENEQQWPVRSINHASLISALSRDYRNLKPSAVAPQRKMPLDD
TKLIIHQTLSVLEDIVENISGESTKSRQICYQSLQESVQVSLALFPAFIHQSDVTDEMLS
FFLTLFRGLRVQMGVPFTEQIIQTFLNMFTREQLAESILHEGSTGCRVVEKFLKILQVVV
QEPGQVFKPFLPSIIALCMEQVYPIIAERPSPDVKAELFELLFRTLHHNWRYFFKSTVLA
SVQRGIAEEQMENEPQFSAIMQAFGQSFLQPDIHLFKQNLFYLETLNTKQKLYHKKIFRT
AMLFQFVNVLLQVLVHKSHDLLQEEIGIAIYNMASVDFDGFFAAFLPEFLTSCDGVDANQ
KSVLGRNFKMDRDLPSFTQNVHRLVNDLRYYRLCNDSLPPGTVKL
Target Bioclass
Other
Family
HHIP family
Subcellular location
Cytoplasm; Cell membrane
Function Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Uniprot ID
Q96QV1
Ensemble ID
ENST00000296575.8
HGNC ID
HGNC:14866

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.G489C .
DU145 SNV: p.Q420E .
EGI1 SNV: p.R514L .
HCT15 SNV: p.V562F .
HELA SNV: p.N447S .
IGR37 SNV: p.A339V .
KYM1 SNV: p.G190E .
MFE319 SNV: p.D165N .
NB1 SNV: p.D557Y .
SKOV3 SNV: p.E257K .
SW620 SNV: p.C608Y .
SW948 SNV: p.A642S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C639(1.17)  LDD1573  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0369  CL100 HEK-293T C639(1.17)  LDD1573  [1]
 LDCM0373  CL104 HEK-293T C639(1.49)  LDD1577  [1]
 LDCM0377  CL108 HEK-293T C639(1.39)  LDD1581  [1]
 LDCM0382  CL112 HEK-293T C639(1.13)  LDD1586  [1]
 LDCM0386  CL116 HEK-293T C639(1.39)  LDD1590  [1]
 LDCM0391  CL120 HEK-293T C639(1.39)  LDD1595  [1]
 LDCM0395  CL124 HEK-293T C639(1.89)  LDD1599  [1]
 LDCM0399  CL128 HEK-293T C639(1.41)  LDD1603  [1]
 LDCM0403  CL16 HEK-293T C639(1.32)  LDD1607  [1]
 LDCM0416  CL28 HEK-293T C639(1.30)  LDD1620  [1]
 LDCM0429  CL4 HEK-293T C639(1.29)  LDD1633  [1]
 LDCM0430  CL40 HEK-293T C639(1.18)  LDD1634  [1]
 LDCM0443  CL52 HEK-293T C639(1.13)  LDD1646  [1]
 LDCM0456  CL64 HEK-293T C639(1.17)  LDD1659  [1]
 LDCM0469  CL76 HEK-293T C639(1.42)  LDD1672  [1]
 LDCM0482  CL88 HEK-293T C639(1.64)  LDD1685  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Desert hedgehog protein (DHH) Hedgehog family O43323
Sonic hedgehog protein (SHH) Hedgehog family Q15465

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060